Literature DB >> 23752507

Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model.

John A Moss1, Amanda M Malone, Thomas J Smith, Sean Kennedy, Cali Nguyen, Kathleen L Vincent, Massoud Motamedi, Marc M Baum.   

Abstract

Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

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Year:  2013        PMID： 23752507      PMCID： PMC3719699          DOI： 10.1128/AAC.00547-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

Review 1.  Contraceptive efficacy and tolerability with a novel combined contraceptive vaginal ring, NuvaRing.

Authors:  F Roumen
Journal:  Eur J Contracept Reprod Health Care       Date:  2002-12       Impact factor: 1.848

Review 2.  Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies.

Authors:  David R Friend; Gustavo F Doncel
Journal:  Antiviral Res       Date:  2010-12       Impact factor: 5.970

Review 3.  Advances in microbicide vaginal rings.

Authors:  R Karl Malcolm; Karen-Leigh Edwards; Patrick Kiser; Joseph Romano; Thomas J Smith
Journal:  Antiviral Res       Date:  2010-12       Impact factor: 5.970

Review 4.  Contraceptive vaginal rings: a review.

Authors:  Vivian Brache; Anibal Faundes
Journal:  Contraception       Date:  2010-05-20       Impact factor: 3.375

5.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

Review 6.  Contraceptive vaginal ring.

Authors:  Tessa Madden; Paul Blumenthal
Journal:  Clin Obstet Gynecol       Date:  2007-12       Impact factor: 2.190

7.  Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial.

Authors:  Kristjan Oddsson; Beate Leifels-Fischer; Nilson Roberto de Melo; Dominique Wiel-Masson; Chiara Benedetto; Carole H J Verhoeven; Thom O M Dieben
Journal:  Contraception       Date:  2005-03       Impact factor: 3.375

8.  Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.

Authors:  Salim S Abdool Karim; Angela D M Kashuba; Lise Werner; Quarraisha Abdool Karim
Journal:  Lancet       Date:  2011-07-16       Impact factor: 79.321

9.  A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel.

Authors:  Jill L Schwartz; Wes Rountree; Angela D M Kashuba; Vivian Brache; Mitchell D Creinin; Alfred Poindexter; Brian P Kearney
Journal:  PLoS One       Date:  2011-10-19       Impact factor: 3.240

10.  Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.

Authors:  J Gerardo García-Lerma; Ron A Otten; Shoukat H Qari; Eddie Jackson; Mian-Er Cong; Silvina Masciotra; Wei Luo; Caryn Kim; Debra R Adams; Michael Monsour; Jonathan Lipscomb; Jeffrey A Johnson; David Delinsky; Raymond F Schinazi; Robert Janssen; Thomas M Folks; Walid Heneine
Journal:  PLoS Med       Date:  2008-02       Impact factor: 11.069
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  18 in total

1.  The sheep as a model of preclinical safety and pharmacokinetic evaluations of candidate microbicides.

Authors:  Jonathon D S Holt; David Cameron; Nicola Dias; Jeremy Holding; Alex Muntendam; Freddy Oostebring; Peter Dreier; Lisa Rohan; Jeremy Nuttall
Journal:  Antimicrob Agents Chemother       Date:  2015-04-06       Impact factor: 5.191

2.  Sustained delivery of commensal bacteria from pod-intravaginal rings.

Authors:  Manjula Gunawardana; Madeline Mullen; Jennifer Yoo; Paul Webster; John A Moss; Marc M Baum
Journal:  Antimicrob Agents Chemother       Date:  2014-02-03       Impact factor: 5.191

3.  Preclinical contraceptive development for men and women.

Authors:  Daniel S Johnston; Erwin Goldberg
Journal:  Biol Reprod       Date:  2020-08-04       Impact factor: 4.285

4.  Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release.

Authors:  Ryan S Teller; David C Malaspina; Rachna Rastogi; Justin T Clark; Igal Szleifer; Patrick F Kiser
Journal:  J Control Release       Date:  2015-12-23       Impact factor: 9.776

5.  An intravaginal ring for the sustained delivery of antibodies.

Authors:  Manjula Gunawardana; Marc M Baum; Thomas J Smith; John A Moss
Journal:  J Pharm Sci       Date:  2014-09-17       Impact factor: 3.534

6.  Pharmacokinetics and preliminary safety study of pod-intravaginal rings delivering antiretroviral combinations for HIV prophylaxis in a macaque model.

Authors:  John A Moss; Priya Srinivasan; Thomas J Smith; Irina Butkyavichene; Gilbert Lopez; Amanda A Brooks; Amy Martin; Chuong T Dinh; James M Smith; Marc M Baum
Journal:  Antimicrob Agents Chemother       Date:  2014-06-16       Impact factor: 5.191

7.  Accurate measurement of female genital tract fluid dilution in cervicovaginal lavage samples.

Authors:  Scott A Churchman; John A Moss; Marc M Baum
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2016-03-02       Impact factor: 3.205

8.  Combination Pod-Intravaginal Ring Delivers Antiretroviral Agents for HIV Prophylaxis: Pharmacokinetic Evaluation in an Ovine Model.

Authors:  John A Moss; Irina Butkyavichene; Scott A Churchman; Manjula Gunawardana; Rob Fanter; Christine S Miller; Flora Yang; Jeremiah T Easley; Mark A Marzinke; Craig W Hendrix; Thomas J Smith; Marc M Baum
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

9.  In Vivo Rectal Mucosal Barrier Function Imaging in a Large-Animal Model by Using Confocal Endomicroscopy: Implications for Injury Assessment and Use in HIV Prevention Studies.

Authors:  Gracie Vargas; Kathleen Listiak Vincent; Yong Zhu; David Szafron; Tyra Caitlin Brown; Paula Patricia Villarreal; Nigel Bourne; Gregg N Milligan; Massoud Motamedi
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

10.  Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception.

Authors:  Bhawana Shrestha; Alison Schaefer; Yong Zhu; Jamal Saada; Timothy M Jacobs; Elizabeth C Chavez; Stuart S Olmsted; Carlos A Cruz-Teran; Gabriela Baldeon Vaca; Kathleen Vincent; Thomas R Moench; Samuel K Lai
Journal:  Sci Transl Med       Date:  2021-08-11       Impact factor: 17.956
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