| Literature DB >> 23747727 |
Yanyan Yu1, Bin Wang, Kun Zhang, Zengjie Lei, Yan Guo, Hualiang Xiao, Jun Wang, Lilin Fan, Chunhui Lan, Yanling Wei, Qiang Ma, Li Lin, Chengyi Mao, Xin Yang, Xiaodi Chen, Yan Li, Yun Bai, Dongfeng Chen.
Abstract
Recent studies have elucidated the role of lysine-specific demethylase 1 (LSD1), a member of the histone demethylases, in epigenetic regulation of tumor suppressing/promoting genes and neoplastic growth. However, the expression of LSD1 in patients with esophageal squamous cell carcinoma (ESCC) is still unknown. Here, we reported that LSD1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with ESCC. Compared to EC109 cells, LSD1 expression was unregulated in aggressive cancer cell lines KYSE450 and KYSE150. Knockdown of LSD1 using lentivirus delivery of LSD1-specific shRNA abrogated the migration and invasion of ESCC cells in vitro. Further, a LSD1 inhibitor, tranylcypromine, suppressed H3K4me2 demethylation and attenuated cellular motility and invasiveness in a dose-dependent manner. Taken together, these data suggested that LSD1 was a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in ESCC.Entities:
Keywords: Esophageal squamous cell carcinoma; Invasion; LSD1
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Year: 2013 PMID： 23747727 DOI： 10.1016/j.bbrc.2013.05.123
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575