Literature DB >> 23747125

Clinical course, complication rate and outcome of segmental resection and distraction osteogenesis after chronic tibial osteitis.

Ulrich Spiegl1, Robert Pätzold, Jan Friederichs, Sven Hungerer, Matthias Militz, Volker Bühren.   

Abstract

INTRODUCTION: Radical segmental resection and subsequent distraction osteogenesis are considered the gold standard in the treatment of chronic tibial osteitis. We investigated the clinical course of treatment, particularly with respect to patients' quality of life, and the complication rate associated with this technique.
METHODS: In this prospective case series, 25 patients (22 men, 3 women, average age: 46 years) with chronic post-traumatic tibial osteitis were managed operatively from 2006 to 2009. Standardised treatment included bacterial eradication by segmental resection, bone transport using Ilizarov apparatus, and docking manoeuvre. The follow-up rates during bacterial eradication, bone transport, post docking, and complete osseous consolidation were 100% while follow-up two years after completed consolidation was 76%. The main outcome measurements consisted of the quality of life (Medical Outcomes Study 36-Item Short Form Health Survey (SF-36 score)) and the virtual analogue scale (VAS) of pain during the five stages of therapy. Additionally, all complications and difficulties were documented.
RESULTS: The average defect size was 5.3 cm (range: 3-13). The healing index was 57 days per cm transport (range: 18-172). The overall treatment time averaged 93 weeks (range: 38-183). Patients suffered 22 minor and 13 major complications including one amputation. The average complication rate per patient consisted of 0.88 minor and 0.52 major complications. After the period of bone transport, the physical and mental component summary scores increased continuously. After completed consolidation, the average mental summary score was comparable to a normal collective.
CONCLUSIONS: Distraction osteogenesis is challenging for both the patient and the surgeon. The arduous and demanding nature of the clinical course subjects the patient to considerable mental and physical stress. Thankfully, the average physical and mental status of health continues to improve during the clinical course of treatment. The 2-year success rate of the distraction osteogenesis in an infected tibia is 96%.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID: 23747125     DOI: 10.1016/j.injury.2013.05.003

Source DB:  PubMed          Journal:  Injury        ISSN: 0020-1383            Impact factor:   2.586


  22 in total

1.  Successful treatment of chronic osteomyelitis in children with debridement, antibiotic-laden cement spacer and bone graft substitute.

Authors:  Federico Canavese; Marco Corradin; Ahmad Khan; Mounira Mansour; Marie Rousset; Antoine Samba
Journal:  Eur J Orthop Surg Traumatol       Date:  2016-09-19

2.  Uncultured autogenous adipose-derived regenerative cells promote bone formation during distraction osteogenesis in rats.

Authors:  Issei Nomura; Koji Watanabe; Hidenori Matsubara; Katsuhiro Hayashi; Naotoshi Sugimoto; Hiroyuki Tsuchiya
Journal:  Clin Orthop Relat Res       Date:  2014-12       Impact factor: 4.176

3.  Three-stage limb salvage in tibial fracture related infection with composite bone and soft-tissue defect.

Authors:  Pablo S Corona; Carla Carbonell-Rosell; Matías Vicente; Jordi Serracanta; Kevin Tetsworth; Vaida Glatt
Journal:  Arch Orthop Trauma Surg       Date:  2021-12-22       Impact factor: 3.067

4.  Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis.

Authors:  Feng Wang; Huijuan Qian; Lingchi Kong; Wenbo Wang; Xiaoyu Wang; Ze Xu; Yimin Chai; Jia Xu; Qinglin Kang
Journal:  Int J Biol Sci       Date:  2021-04-24       Impact factor: 6.580

5.  Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis.

Authors:  Leonard Charles Marais; Nando Ferreira
Journal:  Strategies Trauma Limb Reconstr       Date:  2015-04-04

6.  Quality of life and complications at the different stages of bone transport for treatment infected nonunion of the tibia.

Authors:  Hu Wang; Xing Wei; Ping Liu; Ya-Hui Fu; Peng-Fei Wang; Yu-Xuan Cong; Bin-Fei Zhang; Zhong Li; Jin-Lai Lei; Kun Zhang; Yan Zhuang
Journal:  Medicine (Baltimore)       Date:  2017-11       Impact factor: 1.817

7.  Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies.

Authors:  Y Yang; S Lin; B Wang; W Gu; G Li
Journal:  Bone Joint Res       Date:  2017-06       Impact factor: 5.853

8.  Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis.

Authors:  Yachao Jia; Yu Zhu; Shuo Qiu; Jia Xu; Yimin Chai
Journal:  Stem Cell Res Ther       Date:  2019-01-11       Impact factor: 6.832

Review 9.  Ilizarov bone transport and treatment of critical-sized tibial bone defects: a narrative review.

Authors:  Kemal Aktuglu; Kubilay Erol; Arman Vahabi
Journal:  J Orthop Traumatol       Date:  2019-04-16

10.  Exploring the Mechanism of Total Flavonoids of Drynariae Rhizoma to Improve Large Bone Defects by Network Pharmacology and Experimental Assessment.

Authors:  Weipeng Sun; Minying Li; Lei Xie; Zhexing Mai; Yan Zhang; Lieliang Luo; Zijian Yan; Zige Li; Hang Dong; Feng Huang; Zhen Shen; Ziwei Jiang
Journal:  Front Pharmacol       Date:  2021-05-31       Impact factor: 5.810

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