Literature DB >> 23746275

Leptin in joint and bone diseases: new insights.

M Scotece1, J Conde, V Lopez, F Lago, J Pino, J J Gomez-Reino, O Gualillo.   

Abstract

Leptin is an adipokine with pleiotropic actions that regulates food intake, energy metabolism, inflammation and immunity, and also participates in the complex mechanism that regulates skeleton biology, both at bone and cartilage level. Leptin is increased in obesity and contributes to the "low-grade inflammatory state" of obese subjects causing a cluster of metabolic aberrations that affects joints and bone. In this review, we report the most recent research advances about the role of leptin in bone and cartilage function and its implication in inflammatory and degenerative joint diseases, such as osteoarthritis, rheumatoid arthritis and osteoporosis.

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Year:  2013        PMID： 23746275     DOI： 10.2174/0929867311320270006

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  9 in total

1.  Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content--data from the Osteoarthritis Initiative.

Authors:  J Diepold; A Ruhdorfer; T Dannhauer; W Wirth; E Steidle; F Eckstein
Journal:  Ann Anat       Date:  2015-01-31       Impact factor: 2.698

Review 2.  Adipokines in bone disease.

Authors:  Elena Neumann; Susann Junker; Georg Schett; Klaus Frommer; Ulf Müller-Ladner
Journal:  Nat Rev Rheumatol       Date:  2016-04-15       Impact factor: 20.543

3.  Intra- and inter-observer reliability of quantitative analysis of the infra-patellar fat pad and comparison between fat- and non-fat-suppressed imaging--Data from the osteoarthritis initiative.

Authors:  E Steidle-Kloc; W Wirth; A Ruhdorfer; T Dannhauer; F Eckstein
Journal:  Ann Anat       Date:  2015-11-10       Impact factor: 2.698

4.  Leptin modulates autophagy in human CD4+CD25- conventional T cells.

Authors:  Silvana Cassano; Valentina Pucino; Claudia La Rocca; Claudio Procaccini; Veronica De Rosa; Gianni Marone; Giuseppe Matarese
Journal:  Metabolism       Date:  2014-06-19       Impact factor: 8.694

Review 5.  Serum leptin levels may be correlated with cerebral infarction.

Authors:  Kun-Bin Li; Xian-Li Yao; Ping-Ge Sun; Zhi-Yuan Wu; Xiao-Xing Li; Jun-Qi Liu; Yi-Lan Li
Journal:  J Res Med Sci       Date:  2016-01-28       Impact factor: 1.852

6.  Human adipose-derived mesenchymal stem cells attenuate collagen antibody-induced autoimmune arthritis by inducing expression of FCGIIB receptors.

Authors:  Hyoju Yi; Kwi Young Kang; Youngkyun Kim; Hyerin Jung; Yeri Alice Rim; Narae Park; Juryun Kim; Seung Min Jung; Sung-Hwan Park; Ji Hyeon Ju
Journal:  BMC Musculoskelet Disord       Date:  2015-07-27       Impact factor: 2.362

7.  Upregulation of Bone Morphogenetic Protein-2 Synthesis and Consequent Collagen II Expression in Leptin-stimulated Human Chondrocytes.

Authors:  Shun-Fu Chang; Rong-Ze Hsieh; Kuo-Chin Huang; Cheng Allen Chang; Fang-Yao Chiu; Hsing-Chun Kuo; Cheng-Nan Chen; Yu-Ping Su
Journal:  PLoS One       Date:  2015-12-04       Impact factor: 3.240

8.  Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in vivo and in vitro.

Authors:  Ying-Chao Han; Bin Ma; Song Guo; Mingjie Yang; Li-Jun Li; Shan-Jin Wang; Jun Tan
Journal:  J Cell Mol Med       Date:  2018-01-26       Impact factor: 5.310

9.  Network and pathway-based analyses of genes associated with osteoporosis.

Authors:  Huijie Gu; Zhongyue Huang; Guangnan Chen; Kaifeng Zhou; Yiming Zhang; Jiong Chen; Jun Xu; Xiaofan Yin
Journal:  Medicine (Baltimore)       Date:  2020-02       Impact factor: 1.817
  9 in total

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