Literature DB >> 10771836

Diagnosis and management of ambiguous genitalia.

L D Sherman1.   

Abstract

The diagnosis and management of a newborn with ambiguous genitalia is a diagnostic challenge. Rapid medical evaluation is necessary to uncover and treat potentially life-threatening illnesses, and to allay the psychological stress placed on new parents awaiting announcement of their baby's sex of rearing. Understanding the mechanisms of sexual differentiation can facilitate this task for the physician faced with this dilemma. This article reviews these mechanisms and suggests a logical approach to handling the work-up and treatment plan.

Entities:  

Mesh：

Year:  1997        PMID： 10771836     DOI： 10.1007/bf02752444

Source DB:  PubMed          Journal:  Indian J Pediatr        ISSN： 0019-5456            Impact factor:   1.967


  19 in total

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Journal:  Am J Med       Date:  1965-04       Impact factor: 4.965

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Journal:  Recent Prog Horm Res       Date:  1973

3.  Syndrome of androgen insensitivity in man: absence of 5 alpha-dihydrotestosterone binding protein in skin fibroblasts.

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Journal:  J Clin Endocrinol Metab       Date:  1974-06       Impact factor: 5.958

Review 4.  Female pseudohermaphroditism due to a maternal adrenocortical tumor.

Authors:  J M Kirk; L A Perry; W S Shand; R S Kirby; G M Besser; M O Savage
Journal:  J Clin Endocrinol Metab       Date:  1990-05       Impact factor: 5.958

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Authors:  K W Feldman; D W Smith
Journal:  J Pediatr       Date:  1975-03       Impact factor: 4.406

Review 6.  Prenatal diagnosis of 45,X/46,XY mosaicism--a review and update.

Authors:  L Y Hsu
Journal:  Prenat Diagn       Date:  1989-01       Impact factor: 3.050

7.  Molecular genetics of steroid 5 alpha-reductase 2 deficiency.

Authors:  A E Thigpen; D L Davis; A Milatovich; B B Mendonca; J Imperato-McGinley; J E Griffin; U Francke; J D Wilson; D W Russell
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

8.  Male pseudohermaphroditism due to 17 alpha-hydroxylase deficiency.

Authors:  M I New
Journal:  J Clin Invest       Date:  1970-10       Impact factor: 14.808

Review 9.  Molecular basis of mammalian sexual determination: activation of Müllerian inhibiting substance gene expression by SRY.

Authors:  C M Haqq; C Y King; E Ukiyama; S Falsafi; T N Haqq; P K Donahoe; M A Weiss
Journal:  Science       Date:  1994-12-02       Impact factor: 47.728

10.  A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

Authors:  J Gubbay; J Collignon; P Koopman; B Capel; A Economou; A Münsterberg; N Vivian; P Goodfellow; R Lovell-Badge
Journal:  Nature       Date:  1990-07-19       Impact factor: 49.962
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