Literature DB >> 23744829

A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.

Akane Hirayama1, Tadashi Eguchi, Fumitaka Kudo.   

Abstract

Natural amino donation: A PLP-dependent aminotransferase PctV, encoded in the pactamycin biosynthetic gene cluster, was found to catalyze the formation of 3-aminobenzoate from 3-dehydroshikimate with L-glutamate as the amino donor. The PctV reaction comprises a transamination and two dehydration reactions. This is the first report of a simple 3-ABA synthase in nature.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  aminobenzoate; biosynthesis; dehydroshikimate; natural products; pactamycin

Mesh：

Substances：

Year:  2013        PMID： 23744829     DOI： 10.1002/cbic.201300153

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  6 in total

1.  Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis.

Authors:  Hai P Nguyen; Kenichi Yokoyama
Journal:  Biochemistry       Date:  2019-06-12       Impact factor: 3.162

2.  Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine.

Authors:  Audrey E Yñigez-Gutierrez; Brian O Bachmann
Journal:  J Med Chem       Date:  2019-04-26       Impact factor: 7.446

Review 3.  The secondary metabolite pactamycin with potential for pharmaceutical applications: biosynthesis and regulation.

Authors:  Auday A Eida; Taifo Mahmud
Journal:  Appl Microbiol Biotechnol       Date:  2019-04-25       Impact factor: 4.813

4.  Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum.

Authors:  Wei Zhou; Priyapan Posri; Mostafa E Abugrain; Alexandra J Weisberg; Jeff H Chang; Taifo Mahmud
Journal:  ACS Chem Biol       Date:  2020-12-07       Impact factor: 5.100

5.  Exploiting the Substrate Promiscuity of Hydroxycinnamoyl-CoA:Shikimate Hydroxycinnamoyl Transferase to Reduce Lignin.

Authors:  Aymerick Eudes; Jose H Pereira; Sasha Yogiswara; George Wang; Veronica Teixeira Benites; Edward E K Baidoo; Taek Soon Lee; Paul D Adams; Jay D Keasling; Dominique Loqué
Journal:  Plant Cell Physiol       Date:  2016-02-08       Impact factor: 4.927

6.  Glycosylation of acyl carrier protein-bound polyketides during pactamycin biosynthesis.

Authors:  Auday A Eida; Mostafa E Abugrain; Corey J Brumsted; Taifo Mahmud
Journal:  Nat Chem Biol       Date:  2019-07-15       Impact factor: 15.040
  6 in total

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