Literature DB >> 23744512

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

Xiaoying Bian1, Jun Fu, Alberto Plaza, Jennifer Herrmann, Dominik Pistorius, A Francis Stewart, Youming Zhang, Rolf Müller.   

Abstract

Releasing the cytopath: We have identified an N-myristoyl-D-asparagine (1) as the free N-terminal prodrug scaffold in cytopathogenic Escherichia coli strains expressing the colibactin gene cluster. Colibactin is released in vivo upon cleavage of precolibactin. We provide for the first time in vivo evidence of the prodrug-like release mechanism of colibactin.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  E. coli Nissle; biosynthesis; colibactin; gene expression; prodrug maturation

Mesh：

Substances：

Year:  2013        PMID： 23744512     DOI： 10.1002/cbic.201300208

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  48 in total

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