Literature DB >> 23740675

Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy.

Jinqiang Wang1, Xuanrong Sun, Weiwei Mao, Weilin Sun, Jianbin Tang, Meihua Sui, Youqing Shen, Zhongwei Gu.   

Abstract

A prodrug forms nanocapsules responsive to tumor GSH/ROS heterogeneity releasing the parent drug SN38 via thiolysis in the presence of GSH (glutathione) or via enhanced hydrolysis due to ROS (reactive oxygen species)-oxidation of the linker, giving rise to high in vitro cytotoxicity and in vivo anticancer therapeutic activity. The nanocapsules are a suitable size for tumor targeting by means of the EPR effect and have a fixed SN38 loading content of 35 wt%, ideal for translational nanomedicine.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  drug delivery; nanocapsules; nanomedicine; self-assembling prodrug; triggered release

Mesh：

Substances：

Year:  2013        PMID： 23740675     DOI： 10.1002/adma.201300929

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  40 in total

1.  Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.

Authors:  Bi Wang; Simon Van Herck; Yong Chen; Xiangyang Bai; Zifu Zhong; Kim Deswarte; Bart N Lambrecht; Niek N Sanders; Stefan Lienenklaus; Hans W Scheeren; Sunil A David; Fabian Kiessling; Twan Lammers; Bruno G De Geest; Yang Shi
Journal:  J Am Chem Soc       Date:  2020-06-30       Impact factor: 15.419

2.  Diagnostic and Therapeutic Nanomedicine.

Authors:  Jinmyoung Joo
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 3.  Diverse Applications of Nanomedicine.

Authors:  Beatriz Pelaz; Christoph Alexiou; Ramon A Alvarez-Puebla; Frauke Alves; Anne M Andrews; Sumaira Ashraf; Lajos P Balogh; Laura Ballerini; Alessandra Bestetti; Cornelia Brendel; Susanna Bosi; Monica Carril; Warren C W Chan; Chunying Chen; Xiaodong Chen; Xiaoyuan Chen; Zhen Cheng; Daxiang Cui; Jianzhong Du; Christian Dullin; Alberto Escudero; Neus Feliu; Mingyuan Gao; Michael George; Yury Gogotsi; Arnold Grünweller; Zhongwei Gu; Naomi J Halas; Norbert Hampp; Roland K Hartmann; Mark C Hersam; Patrick Hunziker; Ji Jian; Xingyu Jiang; Philipp Jungebluth; Pranav Kadhiresan; Kazunori Kataoka; Ali Khademhosseini; Jindřich Kopeček; Nicholas A Kotov; Harald F Krug; Dong Soo Lee; Claus-Michael Lehr; Kam W Leong; Xing-Jie Liang; Mei Ling Lim; Luis M Liz-Marzán; Xiaowei Ma; Paolo Macchiarini; Huan Meng; Helmuth Möhwald; Paul Mulvaney; Andre E Nel; Shuming Nie; Peter Nordlander; Teruo Okano; Jose Oliveira; Tai Hyun Park; Reginald M Penner; Maurizio Prato; Victor Puntes; Vincent M Rotello; Amila Samarakoon; Raymond E Schaak; Youqing Shen; Sebastian Sjöqvist; Andre G Skirtach; Mahmoud G Soliman; Molly M Stevens; Hsing-Wen Sung; Ben Zhong Tang; Rainer Tietze; Buddhisha N Udugama; J Scott VanEpps; Tanja Weil; Paul S Weiss; Itamar Willner; Yuzhou Wu; Lily Yang; Zhao Yue; Qian Zhang; Qiang Zhang; Xian-En Zhang; Yuliang Zhao; Xin Zhou; Wolfgang J Parak
Journal:  ACS Nano       Date:  2017-03-14       Impact factor: 15.881

4.  Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

Authors:  Kaimin Cai; Jonathan Yen; Qian Yin; Yang Liu; Ziyuan Song; Stéphane Lezmi; Yanfeng Zhang; Xujuan Yang; William G Helferich; Jianjun Cheng
Journal:  Biomater Sci       Date:  2015-07       Impact factor: 6.843

5.  Developing chemically modified redox-responsive proteins as smart therapeutics.

Authors:  Qiao Tang; Jianxue Wang; Ying Jiang; Meining Zhang; Jin Chang; Qiaobing Xu; Lanqun Mao; Ming Wang
Journal:  Chem Commun (Camb)       Date:  2019-04-25       Impact factor: 6.222

Review 6.  Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.

Authors:  Yuzhe Sun; Edward Davis
Journal:  Nanomaterials (Basel)       Date:  2021-03-16       Impact factor: 5.076

7.  Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy.

Authors:  Cong Luo; Jin Sun; Dan Liu; Bingjun Sun; Lei Miao; Sara Musetti; Jing Li; Xiaopeng Han; Yuqian Du; Lin Li; Leaf Huang; Zhonggui He
Journal:  Nano Lett       Date:  2016-08-08       Impact factor: 11.189

Review 8.  Novel delivery approaches for cancer therapeutics.

Authors:  Ashim K Mitra; Vibhuti Agrahari; Abhirup Mandal; Kishore Cholkar; Chandramouli Natarajan; Sujay Shah; Mary Joseph; Hoang M Trinh; Ravi Vaishya; Xiaoyan Yang; Yi Hao; Varun Khurana; Dhananjay Pal
Journal:  J Control Release       Date:  2015-10-09       Impact factor: 9.776

9.  Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity.

Authors:  Siqin Chen; Yin Zhong; Wufa Fan; Jiajia Xiang; Guowei Wang; Quan Zhou; Jinqiang Wang; Yu Geng; Rui Sun; Zhen Zhang; Ying Piao; Jianguo Wang; Jianyong Zhuo; Hailin Cong; Haiping Jiang; Jun Ling; Zichen Li; Dingding Yang; Xin Yao; Xiao Xu; Zhuxian Zhou; Jianbin Tang; Youqing Shen
Journal:  Nat Biomed Eng       Date:  2021-04-15       Impact factor: 25.671

Review 10.  Nanoparticulation of Prodrug into Medicines for Cancer Therapy.

Authors:  Yuezhou Zhang; Huaguang Cui; Ruiqi Zhang; Hongbo Zhang; Wei Huang
Journal:  Adv Sci (Weinh)       Date:  2021-07-29       Impact factor: 16.806
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.