Literature DB >> 23736977

New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.

Yuji Narukawa1, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura, Fumiyuki Kiuchi.   

Abstract

Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23736977     DOI： 10.1007/s11418-013-0781-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  7 in total

1.  Labdane diterpenes from Leonurus japonicus leaves.

Authors:  Román R Romero-González; Jorge L Avila-Núñez; Lianne Aubert; Miguel E Alonso-Amelot
Journal:  Phytochemistry       Date:  2006-05-11       Impact factor: 4.072

2.  Labdane diterpenoids from Leonurus sibiricus.

Authors:  Hankui Wu; Frank R Fronczek; Daneel Ferreira; Charles L Burandt; Jordan K Zjawiony
Journal:  J Nat Prod       Date:  2011-03-04       Impact factor: 4.050

Review 3.  Enzymology of human cytosolic sulfotransferases.

Authors:  C N Falany
Journal:  FASEB J       Date:  1997-03       Impact factor: 5.191

4.  Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents.

Authors:  Roberta S King; Anasuya A Ghosh; Jinfang Wu
Journal:  Curr Drug Metab       Date:  2006-10       Impact factor: 3.731

5.  Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells.

Authors:  Ayako Saruwatari; Marina Isshiki; Hiroomi Tamura
Journal:  Biol Pharm Bull       Date:  2008-11       Impact factor: 2.233

6.  Labdane diterpenes of Leonurus sibiricus.

Authors:  Dionne M Boalino; Stewart McLean; William F Reynolds; Winston F Tinto
Journal:  J Nat Prod       Date:  2004-04       Impact factor: 4.050

7.  The absolute stereochemistry of a diterpene from Ballota aucheri.

Authors:  Christopher A Gray; Douglas E A Rivett; Michael T Davies-Coleman
Journal:  Phytochemistry       Date:  2003-06       Impact factor: 4.072
  7 in total
  5 in total

1.  Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice.

Authors:  Jangseon Kim; Mi Hye Kim; You Yeon Choi; Jongki Hong; Woong Mo Yang
Journal:  J Nat Med       Date:  2016-02-22       Impact factor: 2.343

2.  Over-Expression of AtPAP1 Transcriptional Factor Enhances Phenolic Acid Production in Transgenic Roots of Leonurus sibiricus L. and Their Biological Activities.

Authors:  Przemysław Sitarek; Tomasz Kowalczyk; Patricia Rijo; Adam J Białas; Marzena Wielanek; Halina Wysokińska; Catarina Garcia; Monika Toma; Tomasz Śliwiński; Ewa Skała
Journal:  Mol Biotechnol       Date:  2018-01       Impact factor: 2.695

3.  Two new diterpenoids from Leonotis leonurus R. Br.

Authors:  Yuji Narukawa; Miyuki Komori; Akiko Niimura; Hitomi Noguchi; Fumiyuki Kiuchi
Journal:  J Nat Med       Date:  2014-09-16       Impact factor: 2.343

4.  The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.

Authors:  Przemysław Sitarek; Ewa Skała; Halina Wysokińska; Marzena Wielanek; Janusz Szemraj; Monika Toma; Tomasz Śliwiński
Journal:  Oxid Med Cell Longev       Date:  2015-12-14       Impact factor: 6.543

5.  Standardization of Leonurus sibiricus L. aerial part and capillary electrophoresis quantitative analysis of its leonurine content.

Authors:  Maneewan Suwatronnakorn; Somchai Issaravanich; Chanida Palanuvej; Nijsiri Ruangrungsi
Journal:  J Adv Pharm Technol Res       Date:  2021-07-16
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.