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Literature DB >> 23732992

Stem cell-based therapy for prevention of delayed fracture union: a randomized and prospective preliminary study.

Meir Liebergall¹, Josh Schroeder, Rami Mosheiff, Zulma Gazit, Zilberman Yoram, Linda Rasooly, Anat Daskal, Amal Khoury, Yoram Weil, Shaul Beyth.

Abstract

Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.

Entities: Chemical Disease Species

Mesh：

Year: 2013 PMID： 23732992 PMCID： PMC3739419 DOI： 10.1038/mt.2013.109

Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454

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