Literature DB >> 23731121

Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

Matthew G LaPorte1, Sammi Tsegay, Ki Bum Hong, Chunliang Lu, Cheng Fang, Lirong Wang, Xiang-Qun Xie, Paul E Floreancig.   

Abstract

A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

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Year:  2013        PMID： 23731121      PMCID： PMC3800499          DOI： 10.1021/co4000387

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  18 in total

1.  Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity.

Authors:  Gangaru Bhaskar; Yuvaraj Arun; Chandrasekar Balachandran; Chandrasekara Saikumar; Paramasivan T Perumal
Journal:  Eur J Med Chem       Date:  2012-02-17       Impact factor: 6.514

Review 2.  New antipsychotics and schizophrenia: a review on efficacy and side effects.

Authors:  Alessandro Serretti; Diana De Ronchi; Cristina Lorenzi; Domenico Berardi
Journal:  Curr Med Chem       Date:  2004-02       Impact factor: 4.530

3.  Ropinirole in the treatment of Parkinson's disease.

Authors:  T A Zesiewicz; R A Hauser
Journal:  Expert Opin Investig Drugs       Date:  1999-05       Impact factor: 6.206

4.  Data mining a small molecule drug screening representative subset from NIH PubChem.

Authors:  Xiang-Qun Xie; Jian-Zhong Chen
Journal:  J Chem Inf Model       Date:  2008-02-27       Impact factor: 4.956

5.  Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.

Authors:  Jacob P MacDonald; Joseph J Badillo; Gary E Arevalo; Abel Silva-García; Annaliese K Franz
Journal:  ACS Comb Sci       Date:  2012-04-02       Impact factor: 3.784

6.  Stereoselective synthesis of spirooxindole amides through nitrile hydrozirconation.

Authors:  Chunliang Lu; Qing Xiao; Paul E Floreancig
Journal:  Org Lett       Date:  2010-10-20       Impact factor: 6.005

7.  Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular Heck reaction.

Authors:  Larry E Overman; Donald A Watson
Journal:  J Org Chem       Date:  2006-03-31       Impact factor: 4.354

Review 8.  Strategies for the enantioselective synthesis of spirooxindoles.

Authors:  Nicolas R Ball-Jones; Joseph J Badillo; Annaliese K Franz
Journal:  Org Biomol Chem       Date:  2012-05-14       Impact factor: 3.876

9.  Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization.

Authors:  Chunhui Dai; Bo Liang; Corey R J Stephenson
Journal:  Beilstein J Org Chem       Date:  2012-07-02       Impact factor: 2.883

10.  Complete transfer of chirality in an intramolecular, thermal [2 + 2] cycloaddition of allene-ynes to form non-racemic spirooxindoles.

Authors:  Kay M Brummond; Joshua M Osbourn
Journal:  Beilstein J Org Chem       Date:  2011-05-12       Impact factor: 2.883
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