BACKGROUND: It is important to establish an early diagnosis of the Marfan Syndrome (MFS) for providing an adequate pharmacological or surgical therapy. Nevertheless, this diagnosis may be complex, given the multi-organic involvement of this disease. AIMS: In this work, we evaluated the oral phenotype in a group of paediatric patients with a clinical diagnosis of MFS, to quantify the association of the oro-facial defects with other systemic alterations. SETTINGS AND DESIGN: Paediatric subjects who were aged, with a clinical diagnosis of MFS, were selected from our regional Marfan monitoring unit. METHODS AND MATERIAL: All the patients were subjected to Paediatric Dentistry examinations and a radiological screening with Panoramic and Cephalometric X-Rays. The aortic dilation (Aortic Z-score value), the hyperlaxity of the ligaments and scoliosis were evaluated by cardio-surgical and orthopaedics specialists. STATISTICAL ANALYSIS: The correlations between the oral and systemic alterations were analyzed by using the chi square test for the nominal variables. RESULTS AND CONCLUSIONS: We found a significant correlation of the Aortic Z - score with multiple oral defects which included retrognathia, malar hypoplasia, cross bite, oral respiration and an ogival palate. An association of the oral defects with hyperlaxity of the ligaments and scoliosis was also found. Thus, the data suggested that dentists should be more involved in a multidisciplinary approach, to provide an early MFS diagnosis in paediatric patients.
BACKGROUND: It is important to establish an early diagnosis of the Marfan Syndrome (MFS) for providing an adequate pharmacological or surgical therapy. Nevertheless, this diagnosis may be complex, given the multi-organic involvement of this disease. AIMS: In this work, we evaluated the oral phenotype in a group of paediatric patients with a clinical diagnosis of MFS, to quantify the association of the oro-facial defects with other systemic alterations. SETTINGS AND DESIGN: Paediatric subjects who were aged, with a clinical diagnosis of MFS, were selected from our regional Marfan monitoring unit. METHODS AND MATERIAL: All the patients were subjected to Paediatric Dentistry examinations and a radiological screening with Panoramic and Cephalometric X-Rays. The aortic dilation (Aortic Z-score value), the hyperlaxity of the ligaments and scoliosis were evaluated by cardio-surgical and orthopaedics specialists. STATISTICAL ANALYSIS: The correlations between the oral and systemic alterations were analyzed by using the chi square test for the nominal variables. RESULTS AND CONCLUSIONS: We found a significant correlation of the Aortic Z - score with multiple oral defects which included retrognathia, malar hypoplasia, cross bite, oral respiration and an ogival palate. An association of the oral defects with hyperlaxity of the ligaments and scoliosis was also found. Thus, the data suggested that dentists should be more involved in a multidisciplinary approach, to provide an early MFS diagnosis in paediatric patients.
Authors: Bart L Loeys; Harry C Dietz; Alan C Braverman; Bert L Callewaert; Julie De Backer; Richard B Devereux; Yvonne Hilhorst-Hofstee; Guillaume Jondeau; Laurence Faivre; Dianna M Milewicz; Reed E Pyeritz; Paul D Sponseller; Paul Wordsworth; Anne M De Paepe Journal: J Med Genet Date: 2010-07 Impact factor: 6.318
Authors: Judith E Allanson; Christopher Cunniff; H Eugene Hoyme; Julie McGaughran; Max Muenke; Giovanni Neri Journal: Am J Med Genet A Date: 2009-01 Impact factor: 2.802
Authors: Lily Pollock; Ashley Ridout; James Teh; Colin Nnadi; Dionisios Stavroulias; Alex Pitcher; Edward Blair; Paul Wordsworth; Tonia L Vincent Journal: Curr Rheumatol Rep Date: 2021-11-26 Impact factor: 4.592