OBJECTIVE: To investigate the ameliorative effect of dietary inclusion of garlic (Allium sativum) on gentamycin-induced hepatotoxicity in rats. METHODS: Adult male rats were randomly divided into four groups with six animals in each group. Groups 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2% and 4% garlic respectively for 27 d prior to gentamycin administration. Hepatotoxicity was induced by the intraperitoneal administration of gentamycin (100 mg/kg body weight) for 3 d. The liver and plasma were studied for hepatotoxicity and antioxidant indices. RESULTS: Gentamycin induces hepatic damage as revealed by significant (P<0.05) elevation of liver damage marker enzymes (aspartate transaminase and alanine aminotransferase) and reduction in plasma albumin level. Gentamycin also caused a significant (P<0.05) alteration in plasma and liver enzymatic (catalase, glutathione and super oxygen dehydrogenises) and non-enzymatic (glutathione and vitamin C) antioxidant indices with concomitant increase in the malondialdehyde content; however, there was a significant (P<0.05) restoration of the antioxidant status coupled with significant (P<0.05) decrease in the tissues' malondialdehyde content, following consumption of diets containing garlic. CONCLUSIONS: These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity, improve antioxidant status and modulate oxidative stress; a function attributed to their phenolic constituents.
OBJECTIVE: To investigate the ameliorative effect of dietary inclusion of garlic (Allium sativum) on gentamycin-induced hepatotoxicity in rats. METHODS: Adult male rats were randomly divided into four groups with six animals in each group. Groups 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2% and 4% garlic respectively for 27 d prior to gentamycin administration. Hepatotoxicity was induced by the intraperitoneal administration of gentamycin (100 mg/kg body weight) for 3 d. The liver and plasma were studied for hepatotoxicity and antioxidant indices. RESULTS:Gentamycin induces hepatic damage as revealed by significant (P<0.05) elevation of liver damage marker enzymes (aspartate transaminase and alanine aminotransferase) and reduction in plasma albumin level. Gentamycin also caused a significant (P<0.05) alteration in plasma and liver enzymatic (catalase, glutathione and super oxygen dehydrogenises) and non-enzymatic (glutathione and vitamin C) antioxidant indices with concomitant increase in the malondialdehyde content; however, there was a significant (P<0.05) restoration of the antioxidant status coupled with significant (P<0.05) decrease in the tissues' malondialdehyde content, following consumption of diets containing garlic. CONCLUSIONS: These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity, improve antioxidant status and modulate oxidative stress; a function attributed to their phenolic constituents.
Authors: H Bliddal; A Rosetzsky; P Schlichting; M S Weidner; L A Andersen; H H Ibfelt; K Christensen; O N Jensen; J Barslev Journal: Osteoarthritis Cartilage Date: 2000-01 Impact factor: 6.576
Authors: S C Penna; M V Medeiros; F S C Aimbire; H C C Faria-Neto; J A A Sertié; R A B Lopes-Martins Journal: Phytomedicine Date: 2003 Impact factor: 5.340
Authors: Donald G Stump; Melissa J Beck; Ann Radovsky; Robert H Garman; Lester L Freshwater; Larry P Sheets; M Sue Marty; John M Waechter; Stephen S Dimond; John P Van Miller; Ronald N Shiotsuka; Dieter Beyer; Anne H Chappelle; Steven G Hentges Journal: Toxicol Sci Date: 2010-02-17 Impact factor: 4.849
Authors: Abdulrahman K Al-Asmari; R Abbasmanthiri; Abdulrahman M Al-Elewi; Saud Al-Omani; Saeed Al-Asmary; Sarah A Al-Asmari Journal: J Toxicol Date: 2014-12-03