Literature DB >> 2373024

Phospholipase C isozymes: structural and functional similarities.

R Kriz1, L L Lin, L Sultzman, C Ellis, C H Heldin, T Pawson, J Knopf.   

Abstract

Phospholipase C (PLC) is shown to comprise at least nine isoforms. These isoforms can be separated into three structurally related classes. Within a class the isozymes have similar enzymological properties. In the case of the PLC gamma class, both isoforms may be regulated by tyrosine phosphorylation. For PLC gamma 1 we show that the tyrosine phosphorylation sites are contained within the SH2/SH3 region or 'modulatory domain'. The overexpression of PLC gamma 1 in Rat-2 cells results in increased phosphatidylinositol breakdown in response to PDGF treatment, demonstrating that PLC gamma 1 mediates this response. We note that thrombin activates PLC gamma 1 in addition to other PLC isoforms.

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Year:  1990        PMID： 2373024     DOI： 10.1002/9780470513927.ch8

Source DB:  PubMed          Journal:  Ciba Found Symp        ISSN： 0300-5208


  21 in total

1.  Roles of phospholipase C beta2 in chemoattractant-elicited responses.

Authors:  H Jiang; Y Kuang; Y Wu; W Xie; M I Simon; D Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  Src homology region 2 domains direct protein-protein interactions in signal transduction.

Authors:  M F Moran; C A Koch; D Anderson; C Ellis; L England; G S Martin; T Pawson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

Review 3.  Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors.

Authors:  S Cockcroft; G M Thomas
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

4.  Localization of phospholipase C-gamma 1 to mouse chromosome 2.

Authors:  K K Nelson; J L Knopf; L D Siracusa
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

Authors:  D Wu; A Katz; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

6.  Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.

Authors:  V R Lo Vasco; M Leopizzi; C Puggioni; C Della Rocca; R Businaro
Journal:  Mol Cell Biochem       Date:  2014-06-06       Impact factor: 3.396

7.  Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila.

Authors:  P A Ferreira; R D Shortridge; W L Pak
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

8.  Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

Authors:  J S Flick; J Thorner
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

9.  A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

Authors:  W E Payne; M Fitzgerald-Hayes
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

10.  Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).

Authors:  K M Pumiglia; L F Lau; C K Huang; S Burroughs; M B Feinstein
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857
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