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Literature DB >> 9223297

Roles of phospholipase C beta2 in chemoattractant-elicited responses.

H Jiang¹, Y Kuang, Y Wu, W Xie, M I Simon, D Wu.

Abstract

The physiological roles of phospholipase C (PLC) beta2 in hematopoiesis, leukocyte function, and host defense against infection were investigated using a mouse line that lacks PLC beta2. PLC beta2 deficiency did not affect hematopoiesis, but it blocked chemoattractant-induced Ca2+ release, superoxide production, and MAC-1 up-regulation in neutrophils. In view of these effects, it was surprising that the absence of PLC beta2 enhanced chemotaxis of different leukocyte populations and sensitized the in vivo response of the PLC beta2-deficient mice to bacteria, viruses, and immune complexes. These data raise questions about the roles that PLC beta2 may play in signal transduction induced by chemoattractants in leukocytes.

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Year: 1997 PMID： 9223297 PMCID： PMC21539 DOI： 10.1073/pnas.94.15.7971

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

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58 in total

1. Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.

Authors: I Davignon; M D Catalina; D Smith; J Montgomery; J Swantek; J Croy; M Siegelman; T M Wilkie
Journal: Mol Cell Biol Date: 2000-02 Impact factor: 4.272

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Journal: EMBO J Date: 2001-02-15 Impact factor: 11.598

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Authors: Aurelie Gresset; John Sondek; T Kendall Harden
Journal: Subcell Biochem Date: 2012

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Authors: Jong-Ik Hwang; Iain D C Fraser; Sangdun Choi; Xiao-Feng Qin; Melvin I Simon
Journal: Proc Natl Acad Sci U S A Date: 2003-12-29 Impact factor: 11.205

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Authors: Wenbin Xiao; Yuko Kawakami; Toshiaki Kawakami
Journal: Immunol Res Date: 2013-05 Impact factor: 2.829

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Journal: J Biol Chem Date: 2010-10-29 Impact factor: 5.157