John J Gildea1, Julia M Carlson1, Cynthia D Schoeffel2, Robert M Carey2, Robin A Felder3. 1. Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA. 2. Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Internal Medicine, The University of Virginia Health System, Charlottesville, VA 22908, USA. 3. Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: raf7k@virginia.edu.
Abstract
OBJECTIVES: To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake. DESIGN AND METHODS: Human urinary exosomal miRNome was examined by microarray. RESULTS: Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity. CONCLUSION: The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.
OBJECTIVES: To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake. DESIGN AND METHODS: Human urinary exosomal miRNome was examined by microarray. RESULTS: Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity. CONCLUSION: The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.
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