Literature DB >> 23722618

Resveratrol derived butyrylcholinesterase inhibitors.

René Csuk1, Sabrina Albert, Ralph Kluge, Dieter Ströhl.   

Abstract

Novel polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to inhibit the enzymes acetyl- and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94-fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Acetylcholinesterase; Alzheimer disease; Butyrylcholinesterase; Resveratrol analogs

Mesh：

Substances：

Year:  2013        PMID： 23722618     DOI： 10.1002/ardp.201300051

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  5 in total

1.  The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans.

Authors:  Nadine Fischer; Christian Büchter; Karoline Koch; Sabrina Albert; René Csuk; Wim Wätjen
Journal:  J Pharm Pharmacol       Date:  2016-11-23       Impact factor: 3.765

Review 2.  Resveratrol and Alzheimer's Disease: Mechanistic Insights.

Authors:  Touqeer Ahmed; Sehrish Javed; Sana Javed; Ameema Tariq; Dunja Šamec; Silvia Tejada; Seyed Fazel Nabavi; Nady Braidy; Seyed Mohammad Nabavi
Journal:  Mol Neurobiol       Date:  2016-03-19       Impact factor: 5.590

3.  In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and β-Secretase Inhibitors with Antioxidant Properties.

Authors:  Malose J Mphahlele; Emmanuel N Agbo; Garland K More; Samantha Gildenhuys
Journal:  Antioxidants (Basel)       Date:  2021-04-22

4.  Design, synthesis and biological evaluation of tricyclic pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one scaffolds as selective BuChE inhibitors.

Authors:  Guo-Liang Qiu; Shao-Sheng He; Shi-Chao Chen; Bo Li; Hui-Hui Wu; Jing Zhang; Wen-Jian Tang
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

5.  Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations.

Authors:  You Zhou; Xin Lu; Hongyu Yang; Yao Chen; Feng Wang; Jifu Li; Zhiran Tang; Xifei Cheng; Yingbin Yang; Li Xu; Qingyou Xia
Journal:  Molecules       Date:  2019-11-20       Impact factor: 4.411
  5 in total

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