Literature DB >> 23722553

Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.

Prasanta Dutta1, Anne Le, David L Vander Jagt, Takashi Tsukamoto, Gary V Martinez, Chi V Dang, Robert J Gillies.   

Abstract

Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor reduced conversion of (13)C-pyruvate to alanine without affecting conversion of pyruvate to lactate. These results illustrate the ability to monitor biomarkers for responses to antimetabolic therapy in real-time, paving the way for clinical development of imaging biomarkers to monitor metabolic pharmacodynamics. ©2013 AACR.

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Year:  2013        PMID： 23722553      PMCID： PMC3736580          DOI： 10.1158/0008-5472.CAN-13-0465

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  20 in total

1.  LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.

Authors:  R D GOLDMAN; N O KAPLAN; T C HALL
Journal:  Cancer Res       Date:  1964-04       Impact factor: 12.701

2.  Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Authors:  John Kurhanewicz; Daniel B Vigneron; Kevin Brindle; Eduard Y Chekmenev; Arnaud Comment; Charles H Cunningham; Ralph J Deberardinis; Gary G Green; Martin O Leach; Sunder S Rajan; Rahim R Rizi; Brian D Ross; Warren S Warren; Craig R Malloy
Journal:  Neoplasia       Date:  2011-02       Impact factor: 5.715

3.  13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

Authors:  Simon Hu; Asha Balakrishnan; Robert A Bok; Brittany Anderton; Peder E Z Larson; Sarah J Nelson; John Kurhanewicz; Daniel B Vigneron; Andrei Goga
Journal:  Cell Metab       Date:  2011-07-06       Impact factor: 27.287

4.  Cellular applications of 31P and 13C nuclear magnetic resonance.

Authors:  R G Shulman; T R Brown; K Ugurbil; S Ogawa; S M Cohen; J A den Hollander
Journal:  Science       Date:  1979-07-13       Impact factor: 47.728

5.  Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

Authors:  Klaes Golman; René In't Zandt; Mathilde Lerche; Rikard Pehrson; Jan Henrik Ardenkjaer-Larsen
Journal:  Cancer Res       Date:  2006-11-15       Impact factor: 12.701

6.  Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

Authors:  Anne Le; Andrew N Lane; Max Hamaker; Sminu Bose; Arvin Gouw; Joseph Barbi; Takashi Tsukamoto; Camilio J Rojas; Barbara S Slusher; Haixia Zhang; Lisa J Zimmerman; Daniel C Liebler; Robbert J C Slebos; Pawel K Lorkiewicz; Richard M Higashi; Teresa W M Fan; Chi V Dang
Journal:  Cell Metab       Date:  2012-01-04       Impact factor: 27.287

7.  Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors.

Authors:  E O Aboagye; Z M Bhujwalla; D C Shungu; J D Glickson
Journal:  Cancer Res       Date:  1998-03-01       Impact factor: 12.701

8.  PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.

Authors:  Brian P Lieberman; Karl Ploessl; Limin Wang; Wenchao Qu; Zhihao Zha; David R Wise; Lewis A Chodosh; George Belka; Craig B Thompson; Hank F Kung
Journal:  J Nucl Med       Date:  2011-11-15       Impact factor: 10.057

9.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.

Authors:  Jan H Ardenkjaer-Larsen; Björn Fridlund; Andreas Gram; Georg Hansson; Lennart Hansson; Mathilde H Lerche; Rolf Servin; Mikkel Thaning; Klaes Golman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

10.  Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Authors:  Sam E Day; Mikko I Kettunen; Ferdia A Gallagher; De-En Hu; Mathilde Lerche; Jan Wolber; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Kevin M Brindle
Journal:  Nat Med       Date:  2007-10-28       Impact factor: 53.440
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  37 in total

Review 1.  Small-molecule inhibitors of human LDH5.

Authors:  Carlotta Granchi; Ilaria Paterni; Reshma Rani; Filippo Minutolo
Journal:  Future Med Chem       Date:  2013-10       Impact factor: 3.808

2.  Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

Authors:  Emilia C Calvaresi; Carlotta Granchi; Tiziano Tuccinardi; Valeria Di Bussolo; Robert W Huigens; Hyang Yeon Lee; Rahul Palchaudhuri; Marco Macchia; Adriano Martinelli; Filippo Minutolo; Paul J Hergenrother
Journal:  Chembiochem       Date:  2013-10-31       Impact factor: 3.164

Review 3.  Metabolic modulation of cancer: a new frontier with great translational potential.

Authors:  Adam Kinnaird; Evangelos D Michelakis
Journal:  J Mol Med (Berl)       Date:  2015-01-14       Impact factor: 4.599

4.  Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.

Authors:  Nicholas R Perkons; Omar Johnson; Gabrielle Pilla; Enri Profka; Michael Mercadante; Daniel Ackerman; Terence P F Gade
Journal:  Clin Cancer Res       Date:  2020-06-04       Impact factor: 12.531

5.  Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Authors:  Bradley T Scroggins; Masayuki Matsuo; Ayla O White; Keita Saito; Jeeva P Munasinghe; Carole Sourbier; Kazutoshi Yamamoto; Vivian Diaz; Yoichi Takakusagi; Kazuhiro Ichikawa; James B Mitchell; Murali C Krishna; Deborah E Citrin
Journal:  Clin Cancer Res       Date:  2018-03-29       Impact factor: 12.531

6.  MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.

Authors:  Emelyn H Shroff; Livia S Eberlin; Vanessa M Dang; Arvin M Gouw; Meital Gabay; Stacey J Adam; David I Bellovin; Phuoc T Tran; William M Philbrick; Adolfo Garcia-Ocana; Stephanie C Casey; Yulin Li; Chi V Dang; Richard N Zare; Dean W Felsher
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-11       Impact factor: 11.205

7.  Monitoring chemotherapeutic response by hyperpolarized 13C-fumarate MRS and diffusion MRI.

Authors:  Lionel Mignion; Prasanta Dutta; Gary V Martinez; Parastou Foroutan; Robert J Gillies; Bénédicte F Jordan
Journal:  Cancer Res       Date:  2013-11-27       Impact factor: 12.701

8.  Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane.

Authors:  Yi Rao; Seth Gammon; Niki M Zacharias; Tracy Liu; Travis Salzillo; Yuanxin Xi; Jing Wang; Pratip Bhattacharya; David Piwnica-Worms
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-24       Impact factor: 11.205

9.  Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype.

Authors:  Arthur J Liu; Shivanand Pudakalakatti; Ashvin R Jaiswal; Prasanta Dutta; Priyamvada Jayaprakash; Todd Bartkowiak; Casey R Ager; Zhi-Qiang Wang; Alexandre Reuben; Zachary A Cooper; Cristina Ivan; Zhenlin Ju; Felix Nwajei; Jing Wang; Michael A Davies; R Eric Davis; Jennifer A Wargo; Pratip K Bhattacharya; David S Hong; Michael A Curran
Journal:  Cancer Immunol Res       Date:  2020-09-11       Impact factor: 11.151

Review 10.  Hypoxia and acidosis: immune suppressors and therapeutic targets.

Authors:  Sultan Damgaci; Arig Ibrahim-Hashim; Pedro M Enriquez-Navas; Shari Pilon-Thomas; Albert Guvenis; Robert J Gillies
Journal:  Immunology       Date:  2018-03-30       Impact factor: 7.397
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