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Literature DB >> 23715550

Stem cells in retinal regeneration: past, present and future.

Conor M Ramsden¹, Michael B Powner, Amanda-Jayne F Carr, Matthew J K Smart, Lyndon da Cruz, Peter J Coffey.

Abstract

Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.

Entities: Chemical

Keywords: A ge-related macular degeneration; Clinical trials; Retinitis pigmentosa; Stargardt's disease; Stem cells

Mesh：

Year: 2013 PMID： 23715550 PMCID： PMC3666384 DOI： 10.1242/dev.092270

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

85 in total

1. Embryonic stem cell trials for macular degeneration: a preliminary report.

Authors: Steven D Schwartz; Jean-Pierre Hubschman; Gad Heilwell; Valentina Franco-Cardenas; Carolyn K Pan; Rosaleen M Ostrick; Edmund Mickunas; Roger Gay; Irina Klimanskaya; Robert Lanza
Journal: Lancet Date: 2012-01-24 Impact factor: 79.321

2. VEGF polymorphisms are associated with neovascular age-related macular degeneration.

Authors: Amanda J Churchill; James G Carter; Helen C Lovell; Conor Ramsden; Steven J Turner; Anna Yeung; Julia Escardo; Denize Atan
Journal: Hum Mol Genet Date: 2006-08-29 Impact factor: 6.150

3. Systemically transferred hematopoietic stem cells home to the subretinal space and express RPE-65 in a mouse model of retinal pigment epithelium damage.

Authors: Pelin Atmaca-Sonmez; Yang Li; Yasuyuki Yamauchi; Carrie L Schanie; Suzanne T Ildstad; Henry J Kaplan; Volker Enzmann
Journal: Exp Eye Res Date: 2006-09-01 Impact factor: 3.467

4. Ranibizumab for neovascular age-related macular degeneration.

Authors: Philip J Rosenfeld; David M Brown; Jeffrey S Heier; David S Boyer; Peter K Kaiser; Carol Y Chung; Robert Y Kim
Journal: N Engl J Med Date: 2006-10-05 Impact factor: 91.245

5. Complement factor H variant increases the risk of age-related macular degeneration.

Authors: Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal: Science Date: 2005-03-10 Impact factor: 47.728

6. Early attachment of uncultured retinal pigment epithelium from aged donors onto Bruch's membrane explants.

Authors: I Tsukahara; S Ninomiya; A Castellarin; F Yagi; I K Sugino; M A Zarbin
Journal: Exp Eye Res Date: 2002-02 Impact factor: 3.467

Review 7. RPE transplantation and its role in retinal disease.

Authors: Lyndon da Cruz; Fred K Chen; Ahmad Ahmado; John Greenwood; Pete Coffey
Journal: Prog Retin Eye Res Date: 2007-07-25 Impact factor: 21.198

8. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.

Authors: Atsushi Otani; Michael Ian Dorrell; Karen Kinder; Stacey K Moreno; Steven Nusinowitz; Eyal Banin; John Heckenlively; Martin Friedlander
Journal: J Clin Invest Date: 2004-09 Impact factor: 14.808

9. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.

Authors: Bin Lu; Christopher Malcuit; Shaomei Wang; Sergej Girman; Peter Francis; Linda Lemieux; Robert Lanza; Raymond Lund
Journal: Stem Cells Date: 2009-09 Impact factor: 6.277

10. Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation.

Authors: Shweta Singhal; Bhairavi Bhatia; Hari Jayaram; Silke Becker; Megan F Jones; Phillippa B Cottrill; Peng T Khaw; Thomas E Salt; G Astrid Limb
Journal: Stem Cells Transl Med Date: 2012-03-07 Impact factor: 6.940

85 in total

Review 1. Stem cells and nanomaterials.

Authors: Marie-Claude Hofmann
Journal: Adv Exp Med Biol Date: 2014 Impact factor: 2.622

Review 2. Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells.

Authors: Cuiping Zhao; Qingjie Wang; Sally Temple
Journal: Development Date: 2017-04-15 Impact factor: 6.868

3. Differentiation potential of human adipose tissue derived stem cells into photoreceptors through explants culture and enzyme methods.

Authors: Wei-Wei Xu; Li Huang; Kelvin K L Chong; Doreen S Y Leung; Benjamin F L Li; Zheng-Qin Yin; Yi-Fei Huang; Chi Pui Pang
Journal: Int J Ophthalmol Date: 2017-01-18 Impact factor: 1.779

4. Chapter 4 - Restoring Vision to the Blind: Stem Cells and Transplantation.

Authors:
Journal: Transl Vis Sci Technol Date: 2014-12-30 Impact factor: 3.283

5. Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension.

Authors: Peter D Westenskow; Toshihide Kurihara; Stephen Bravo; Daniel Feitelberg; Zack A Sedillo; Edith Aguilar; Martin Friedlander
Journal: J Vis Exp Date: 2015-01-23 Impact factor: 1.355

Review 6. Methods of induced pluripotent stem cells for clinical application.

Authors: Tomohisa Seki; Keiichi Fukuda
Journal: World J Stem Cells Date: 2015-01-26 Impact factor: 5.326

7. Soluble expression of recomb inant cMyc, Klf4, Oct4, and Sox2 proteins in bacteria and transduction into living cells.

Authors: Guo-Dan Liu; Shi-Feng Zhou; Xu-Chen Ding; Chun-Lai Fang; Shu-Yong Mi; Xiang-Chun Gao; Qing Han
Journal: Int J Ophthalmol Date: 2017-04-18 Impact factor: 1.779