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Literature DB >> 23715547

Stem cell metabolism in tissue development and aging.

Ng Shyh-Chang¹, George Q Daley, Lewis C Cantley.

Abstract

Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to be a mere consequence of the state of a cell, metabolism is now known to play a pivotal role in dictating whether a cell proliferates, differentiates or remains quiescent. Here, we review recent studies of metabolism in stem cells that have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of adult stem cells, and during the reprogramming of somatic cells to pluripotency. These insights promise to inform strategies for the directed differentiation of stem cells and to offer the potential for novel metabolic or pharmacological therapies to enhance regeneration and the treatment of degenerative disease.

Entities: Disease

Keywords: Blastocyst metabolism; Hematopoietic progenitors; Metabolomics; Pluripotent stem cells; Reprogramming

Mesh：

Year: 2013 PMID： 23715547 PMCID： PMC3666381 DOI： 10.1242/dev.091777

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

125 in total

Review 1. Linking functional decline of telomeres, mitochondria and stem cells during ageing.

Authors: Ergün Sahin; Ronald A Depinho
Journal: Nature Date: 2010-03-25 Impact factor: 49.962

2. Hypoxia enhances the generation of induced pluripotent stem cells.

Authors: Yoshinori Yoshida; Kazutoshi Takahashi; Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal: Cell Stem Cell Date: 2009-08-27 Impact factor: 24.633

3. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Authors: Sushma Gurumurthy; Stephanie Z Xie; Brinda Alagesan; Judith Kim; Rushdia Z Yusuf; Borja Saez; Alexandros Tzatsos; Fatih Ozsolak; Patrice Milos; Francesco Ferrari; Peter J Park; Orian S Shirihai; David T Scadden; Nabeel Bardeesy
Journal: Nature Date: 2010-12-02 Impact factor: 49.962

4. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

Authors: Clifford D L Folmes; Timothy J Nelson; Almudena Martinez-Fernandez; D Kent Arrell; Jelena Zlatkovic Lindor; Petras P Dzeja; Yasuhiro Ikeda; Carmen Perez-Terzic; Andre Terzic
Journal: Cell Metab Date: 2011-08-03 Impact factor: 27.287

Review 5. Metabolic control during preimplantation mammalian development.

Authors: H J Leese
Journal: Hum Reprod Update Date: 1995-01 Impact factor: 15.610

6. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila.

Authors: Hwei-Jan Hsu; Leesa LaFever; Daniela Drummond-Barbosa
Journal: Dev Biol Date: 2007-11-17 Impact factor: 3.582

7. Mitochondrial DNA replication during differentiation of murine embryonic stem cells.

Authors: Joao M Facucho-Oliveira; Jon Alderson; Emma C Spikings; Stuart Egginton; Justin C St John
Journal: J Cell Sci Date: 2007-10-30 Impact factor: 5.285

8. Carbon metabolism-mediated myogenic differentiation.

Authors: Abigail L Bracha; Arvind Ramanathan; Sui Huang; Donald E Ingber; Stuart L Schreiber
Journal: Nat Chem Biol Date: 2010-01-17 Impact factor: 15.040

9. Direct cell reprogramming is a stochastic process amenable to acceleration.

Authors: Jacob Hanna; Krishanu Saha; Bernardo Pando; Jeroen van Zon; Christopher J Lengner; Menno P Creyghton; Alexander van Oudenaarden; Rudolf Jaenisch
Journal: Nature Date: 2009-11-08 Impact factor: 49.962

10. Selective blockade of microRNA processing by Lin28.

Authors: Srinivas R Viswanathan; George Q Daley; Richard I Gregory
Journal: Science Date: 2008-02-21 Impact factor: 47.728

223 in total

1. Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment.

Authors: Angel T Chan; Mehmet F Karakas; Styliani Vakrou; Junaid Afzal; Andrew Rittenbach; Xiaoping Lin; Richard L Wahl; Martin G Pomper; Charles J Steenbergen; Benjamin M W Tsui; Jennifer H Elisseeff; M Roselle Abraham
Journal: Biomaterials Date: 2015-09-04 Impact factor: 12.479

Review 2. Accumulation of DNA damage in the aged hematopoietic stem cell compartment.

Authors: Isabel Beerman
Journal: Semin Hematol Date: 2016-11-18 Impact factor: 3.851

3. Density-Dependent Metabolic Heterogeneity in Human Mesenchymal Stem Cells.

Authors: Yijun Liu; Nathalie Muñoz; Bruce A Bunnell; Timothy M Logan; Teng Ma
Journal: Stem Cells Date: 2015-08-14 Impact factor: 6.277

4. Linking HSCs to their youth.

Authors: Eric M Pietras; Emmanuelle Passegué
Journal: Nat Cell Biol Date: 2013-08 Impact factor: 28.824

Review 5. Metabolic requirements for the maintenance of self-renewing stem cells.

Authors: Keisuke Ito; Toshio Suda
Journal: Nat Rev Mol Cell Biol Date: 2014-04 Impact factor: 94.444

Review 6. Surviving change: the metabolic journey of hematopoietic stem cells.

Authors: Latika Kohli; Emmanuelle Passegué
Journal: Trends Cell Biol Date: 2014-04-24 Impact factor: 20.808

Review 7. The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.

Authors: Michael Hadjiargyrou; Regis J O'Keefe
Journal: J Bone Miner Res Date: 2014-11 Impact factor: 6.741