| Literature DB >> 2371139 |
R Vanhoof1, J M Hubrechts, H J Nyssen, E Nulens, J Leger, N de Schepper, E Kupperberg, M L Couvreur.
Abstract
By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration greater than or equal to 8 mg/l) or resistant (minimal inhibiting concentration greater than or equal to 64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam-mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations.Entities:
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Year: 1990 PMID： 2371139 DOI： 10.1007/bf01967603
Source DB: PubMed Journal: Pharm Weekbl Sci ISSN： 0167-6555