Literature DB >> 23710294

At the dawn of a new revolution in life sciences.

František Baluška1, Guenther Witzany.   

Abstract

In a recently published article Sydney Brenner argued that the most relevant scientific revolution in biology at his time was the breakthrough of the role of "information" in biology. The fundamental concept that integrates this new biological "information" with matter and energy is the universal Turing machine and von Neumann's self-reproducing machines. In this article we demonstrate that in contrast to Turing/von Neumann machines living cells can really reproduce themselves. Additionally current knowledge on the roles of non-coding RNAs indicates a radical violation of the central dogma of molecular biology and opens the way to a new revolution in life sciences.

Entities:  

Keywords:  History of science; Information; Non-coding RNAs; Paradigm shift

Year:  2013        PMID: 23710294      PMCID: PMC3654106          DOI: 10.4331/wjbc.v4.i2.13

Source DB:  PubMed          Journal:  World J Biol Chem        ISSN: 1949-8454


  13 in total

1.  Epigenome: the program for human health and disease.

Authors:  Randy L Jirtle
Journal:  Epigenomics       Date:  2009-10       Impact factor: 4.778

2.  Turing centenary: Life's code script.

Authors:  Sydney Brenner
Journal:  Nature       Date:  2012-02-22       Impact factor: 49.962

3.  How the microbial world saved evolution from the scylla of molecular biology and the charybdis of the modern synthesis.

Authors:  Carl R Woese; Nigel Goldenfeld
Journal:  Microbiol Mol Biol Rev       Date:  2009-03       Impact factor: 11.056

4.  Life's code script does not code itself. The machine metaphor for living organisms is outdated.

Authors:  Günther Witzany; František Baluška
Journal:  EMBO Rep       Date:  2012-11-13       Impact factor: 8.807

5.  History of science. The revolution in the life sciences.

Authors:  Sydney Brenner
Journal:  Science       Date:  2012-12-14       Impact factor: 47.728

6.  Widespread horizontal transfer of retrotransposons.

Authors:  Ali Morton Walsh; R Daniel Kortschak; Michael G Gardner; Terry Bertozzi; David L Adelson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-31       Impact factor: 11.205

7.  A theory of biological relativity: no privileged level of causation.

Authors:  Denis Noble
Journal:  Interface Focus       Date:  2011-11-09       Impact factor: 3.906

Review 8.  Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease.

Authors:  Irfan A Qureshi; Mark F Mehler
Journal:  Nat Rev Neurosci       Date:  2012-07-20       Impact factor: 34.870

Review 9.  Oxygen, epigenetic signaling, and the evolution of early life.

Authors:  Albert Jeltsch
Journal:  Trends Biochem Sci       Date:  2013-02-28       Impact factor: 13.807

10.  Does the central dogma still stand?

Authors:  Eugene V Koonin
Journal:  Biol Direct       Date:  2012-08-23       Impact factor: 4.540

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  6 in total

1.  Life is more than a computer running DNA software.

Authors:  František Baluška; Guenther Witzany
Journal:  World J Biol Chem       Date:  2014-08-26

2.  Can subcellular organization be explained only by physical principles?

Authors:  Guenther Witzany; František Baluška
Journal:  Commun Integr Biol       Date:  2015-08-31

Review 3.  Current advances in systems and integrative biology.

Authors:  Scott W Robinson; Marco Fernandes; Holger Husi
Journal:  Comput Struct Biotechnol J       Date:  2014-08-27       Impact factor: 7.271

4.  Life and evolution as physics.

Authors:  Adrian Bejan
Journal:  Commun Integr Biol       Date:  2016-05-09

5.  The biocommunication method: On the road to an integrative biology.

Authors:  Guenther Witzany
Journal:  Commun Integr Biol       Date:  2016-04-08

6.  How to deduce and teach the logical and unambiguous answer, namely L = ∑C, to "What is Life?" using the principles of communication?

Authors:  Arnold De Loof
Journal:  Commun Integr Biol       Date:  2015-07-25
  6 in total

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