Literature DB >> 2370863

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat.

S J Marriott1, P F Lindholm, K M Brown, S D Gitlin, J F Duvall, M F Radonovich, J N Brady.   

Abstract

The human T-cell leukemia/lymphoma virus type I (HTLV-I) trans activator, TAX1, interacts indirectly with a TAX1-responsive element, TRE-2, located at positions -117 to -163 in the viral long terminal repeat. This report describes the characterization of a 36-kilodalton (kDa) protein identified in HeLa nuclear extract which mediates the interaction of TAX1 with TRE-2. Purification of the protein was achieved by zinc chelate chromatography and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The renatured 36-kDa protein bound specifically to a TRE-2 oligonucleotide but not to nonfunctional base substitution mutant probes in a gel retardation assay. Renatured proteins of differing molecular weights were unable to form this complex. In addition, the 36-kDa protein specifically activated transcription from the HTLV-I promoter in vitro. Purified TAX1 protein formed a complex with the TRE-2 oligonucleotide in the presence of the 36-kDa protein, suggesting that indirect interaction of TAX1 with the viral long terminal repeat may be one of the mechanisms by which HTLV-I transcription is regulated.

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Year:  1990        PMID： 2370863      PMCID： PMC360951          DOI： 10.1128/mcb.10.8.4192-4201.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  68 in total

1.  c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

Authors:  M Fujii; P Sassone-Corsi; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

2.  In vitro mutagenesis of the human T-cell leukemia virus types I and II tax genes.

Authors:  A J Cann; J D Rosenblatt; W Wachsman; I S Chen
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

3.  The role of the leucine zipper in the fos-jun interaction.

Authors:  T Kouzarides; E Ziff
Journal:  Nature       Date:  1988-12-15       Impact factor: 49.962

4.  Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.

Authors:  M Fried; D M Crothers
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

5.  Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type I tat proteins occurs in the absence of de novo protein synthesis.

Authors:  K T Jeang; P R Shank; A Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

6.  Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan.

Authors:  V S Kalyanaraman; M G Sarngadharan; Y Nakao; Y Ito; T Aoki; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

7.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Authors:  M Yoshida; I Miyoshi; Y Hinuma
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

8.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

Authors:  J D Dignam; R M Lebovitz; R G Roeder
Journal:  Nucleic Acids Res       Date:  1983-03-11       Impact factor: 16.971

9.  Purification of human fibroblast interferon by zinc chelate chromatography.

Authors:  J W Heine; J Van Damme; M de Ley; A Billiau; P de Somer
Journal:  J Gen Virol       Date:  1981-05       Impact factor: 3.891

10.  Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

Authors:  Y Hinuma; K Nagata; M Hanaoka; M Nakai; T Matsumoto; K I Kinoshita; S Shirakawa; I Miyoshi
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205
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  38 in total

1.  Anti-Rex aptamers as mimics of the Rex-binding element.

Authors:  S Baskerville; M Zapp; A D Ellington
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

Review 2.  Mechanism of action of regulatory proteins encoded by complex retroviruses.

Authors:  B R Cullen
Journal:  Microbiol Rev       Date:  1992-09

3.  Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

Authors:  S Sawada; D R Littman
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

4.  Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I.

Authors:  S D Gitlin; R Bosselut; A Gégonne; J Ghysdael; J N Brady
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

5.  The cellular proto-oncogene product Myb acts as transcriptional activator of the long terminal repeat of human T-lymphotropic virus type I.

Authors:  P Dasgupta; C D Reddy; P Saikumar; E P Reddy
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

6.  Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors.

Authors:  F Bantignies; R Rousset; C Desbois; P Jalinot
Journal:  Mol Cell Biol       Date:  1996-05       Impact factor: 4.272

7.  T-cell receptor/CD28 engagement when combined with prostaglandin E2 treatment leads to potent activation of human T-cell leukemia virus type 1.

Authors:  Nancy Dumais; Marie-Eve Paré; Simon Mercier; Salim Bounou; Susan J Marriot; Benoit Barbeau; Michel J Tremblay
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Selective infection of human T-lymphotropic virus type 1 (HTLV-1)-infected cells by chimeric human immunodeficiency viruses containing HTLV-1 tax response elements in the long terminal repeat.

Authors:  H C Lin; M Bodkin; R B Lal; A B Rabson
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

9.  Activation of human T-cell leukemia virus type 1 tax gene expression in chronically infected T cells.

Authors:  H C Lin; C S Dezzutti; R B Lal; A B Rabson
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

10.  Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway.

Authors:  P F Lindholm; M Tamami; J Makowski; J N Brady
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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