Alan H B Wu1, Frank Wians, Allan Jaffe. 1. Clinical Chemistry Laboratory, Department of Laboratory Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA. wualan@labmed2.ucsf.edu
Abstract
BACKGROUND: Galectin-3 and soluble ST2 (sST2) are novel serum biomarkers of chronic heart failure. METHODS AND RESULTS: The biological variability of galectin-3 and sST2 was measured from a cohort of 17 healthy subjects where blood was taken once every 2 weeks for 8 weeks (n = 4 samples) and from 12 subjects where blood was taken hourly (for galectin-3 only). The analytical, intraindividual, and interindividual variation were measured for galectin-3 (BG Medicine, Waltham, MA) and sST2 (Critical Diagnostics, San Diego, CA). From these measurements, the reference change (RCV) and index of individuality was 39% (hourly) and 61% (weekly) and 1.0 (hourly and weekly) for galectin-3. Corresponding RCV and index of individuality values for sST2 were 30% and 0.25. CONCLUSION: The RCV result for sST2 was lower than the corresponding results for galectin-3, B-type natriuretic peptide, and N-terminal pro-B-type natriuretic peptide. These data suggest that sST2 may be more useful for monitoring long-term heart failure, and galectin-3 may be more useful for the diagnosis of heart failure remodeling.
BACKGROUND:Galectin-3 and soluble ST2 (sST2) are novel serum biomarkers of chronic heart failure. METHODS AND RESULTS: The biological variability of galectin-3 and sST2 was measured from a cohort of 17 healthy subjects where blood was taken once every 2 weeks for 8 weeks (n = 4 samples) and from 12 subjects where blood was taken hourly (for galectin-3 only). The analytical, intraindividual, and interindividual variation were measured for galectin-3 (BG Medicine, Waltham, MA) and sST2 (Critical Diagnostics, San Diego, CA). From these measurements, the reference change (RCV) and index of individuality was 39% (hourly) and 61% (weekly) and 1.0 (hourly and weekly) for galectin-3. Corresponding RCV and index of individuality values for sST2 were 30% and 0.25. CONCLUSION: The RCV result for sST2 was lower than the corresponding results for galectin-3, B-type natriuretic peptide, and N-terminal pro-B-type natriuretic peptide. These data suggest that sST2 may be more useful for monitoring long-term heart failure, and galectin-3 may be more useful for the diagnosis of heart failure remodeling.
Authors: Anahita Ghorbani; Vijeta Bhambhani; Robert H Christenson; Wouter C Meijers; Rudolf A de Boer; Daniel Levy; Martin G Larson; Jennifer E Ho Journal: J Am Coll Cardiol Date: 2018-12-25 Impact factor: 24.094
Authors: A Rogier van der Velde; Wouter C Meijers; Jennifer E Ho; Frank P Brouwers; Michiel Rienstra; Stephan J L Bakker; Anneke C Muller Kobold; Dirk J van Veldhuisen; Wiek H van Gilst; Pim van der Harst; Rudolf A de Boer Journal: Heart Date: 2016-04-15 Impact factor: 5.994
Authors: Stephanie Klein; Ingo Nolte; José Luis Granados-Soler; Philipp Lietz; Maximiliane Sehn; Jonathan Friedemann Raue; Karl Rohn; Eva-Maria Packeiser; Jan-Peter Bach Journal: BMC Vet Res Date: 2022-07-02 Impact factor: 2.792