OBJECTIVE: To examine associations of urinary phthalate levels with blood pressure (BP) and serum triglyceride and lipoprotein levels in children. STUDY DESIGN: We performed a cross-sectional analysis of a subsample of US children aged 6-19 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2008. We quantified exposure to 3 families of phthalates--low molecular weight, high molecular weight and di-2-ethylhexylphthalate (DEHP)--based on molar concentration of urinary metabolites. We assessed descriptive, bivariate, and multivariate associations with BP and lipid levels. RESULTS: Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass index, levels of metabolites of DEHP, a phthalate commonly found in processed foods, were associated with higher age-, sex-, and height-standardized BP. For each log unit (roughly 3-fold) increase in DEHP metabolites, a 0.041 SD unit increase in systolic BP z-score was identified (P = .047). Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products were not associated with BP. Phthalate metabolites were not associated with triglyceride levels, high-density lipoprotein level, or prehypertension. CONCLUSIONS: Dietary phthalate exposure is associated with higher systolic BP in children and adolescents. Further work is needed to confirm these associations, as well as to evaluate opportunities for intervention.
OBJECTIVE: To examine associations of urinary phthalate levels with blood pressure (BP) and serum triglyceride and lipoprotein levels in children. STUDY DESIGN: We performed a cross-sectional analysis of a subsample of US children aged 6-19 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2008. We quantified exposure to 3 families of phthalates--low molecular weight, high molecular weight and di-2-ethylhexylphthalate (DEHP)--based on molar concentration of urinary metabolites. We assessed descriptive, bivariate, and multivariate associations with BP and lipid levels. RESULTS: Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass index, levels of metabolites of DEHP, a phthalate commonly found in processed foods, were associated with higher age-, sex-, and height-standardized BP. For each log unit (roughly 3-fold) increase in DEHP metabolites, a 0.041 SD unit increase in systolic BP z-score was identified (P = .047). Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products were not associated with BP. Phthalate metabolites were not associated with triglyceride levels, high-density lipoprotein level, or prehypertension. CONCLUSIONS: Dietary phthalate exposure is associated with higher systolic BP in children and adolescents. Further work is needed to confirm these associations, as well as to evaluate opportunities for intervention.
Authors: Elaine M Urbina; Thomas R Kimball; Philip R Khoury; Stephen R Daniels; Lawrence M Dolan Journal: J Hypertens Date: 2010-08 Impact factor: 4.844
Authors: Susan L Teitelbaum; Nancy Mervish; Erin L Moshier; Nita Vangeepuram; Maida P Galvez; Antonia M Calafat; Manori J Silva; Barbara L Brenner; Mary S Wolff Journal: Environ Res Date: 2012-01-04 Impact factor: 6.498
Authors: Michael Weitzman; Stephen Cook; Peggy Auinger; Todd A Florin; Stephen Daniels; Michael Nguyen; Jonathan P Winickoff Journal: Circulation Date: 2005-08-01 Impact factor: 29.690
Authors: Hermann Fromme; Ludwig Gruber; Martin Schlummer; Gerd Wolz; Sigrun Böhmer; Jürgen Angerer; Richard Mayer; Bernhard Liebl; Gabriele Bolte Journal: Environ Int Date: 2007-07-03 Impact factor: 9.621
Authors: Manori J Silva; Dana B Barr; John A Reidy; Nicole A Malek; Carolyn C Hodge; Samuel P Caudill; John W Brock; Larry L Needham; Antonia M Calafat Journal: Environ Health Perspect Date: 2004-03 Impact factor: 9.031
Authors: Elise M Philips; Leonardo Trasande; Linda G Kahn; Romy Gaillard; Eric A P Steegers; Vincent W V Jaddoe Journal: Hum Reprod Date: 2019-02-01 Impact factor: 6.918
Authors: Nataša Milošević; Maja Milanović; Jan Sudji; Dragana Bosić Živanović; Stefan Stojanoski; Bojan Vuković; Nataša Milić; Milica Medić Stojanoska Journal: Environ Sci Pollut Res Int Date: 2019-12-06 Impact factor: 4.223
Authors: Andrea L Deierlein; Mary S Wolff; Ashley Pajak; Susan M Pinney; Gayle C Windham; Maida P Galvez; Manori J Silva; Antonia M Calafat; Lawrence H Kushi; Frank M Biro; Susan L Teitelbaum Journal: Epidemiology Date: 2016-07 Impact factor: 4.822