UNLABELLED: Chronic histiocytic intervillositis of the placenta (CHI) is a rare and potentially recurrent disease. Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta. METHODS: We analysed the expression profile of 102 inflammation- and angiogenesis-associated genes with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 16 placentas: CHI (n = 5) and, as controls, villitis of unknown aetiology (VUE, n = 4) and normal placenta (n = 7). RESULTS: Compared to controls, CHI had significantly higher levels of matrix metallopeptidase 9 (MMP9) and transforming growth factor, beta receptor 1 (TGFBR1). MMP14 was lower in VUE than CHI (p < 0.05) and controls (not significant). Chemokine (C-X-C motif) ligand 9 (CXCL9), CXCL12, chemokine (C-C motif) ligand 5 (CCL5) and TIMP metallopeptidase inhibitor 1 (TIMP1) were significantly higher in VUE versus controls but not deregulated in CHI. The expression profile could not clearly discriminate CHI from VUE or controls but a tendency for grouping of massive CHI was found. Angiogenesis-associated factors were not deregulated in CHI. CONCLUSION: The discrepancy of massive histiocytic accumulation and the lack of striking up-regulation of cytokines might be the basis of the non-destructive behaviour of the histiocytes in CHI.
UNLABELLED: Chronic histiocytic intervillositis of the placenta (CHI) is a rare and potentially recurrent disease. Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta. METHODS: We analysed the expression profile of 102 inflammation- and angiogenesis-associated genes with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 16 placentas: CHI (n = 5) and, as controls, villitis of unknown aetiology (VUE, n = 4) and normal placenta (n = 7). RESULTS: Compared to controls, CHI had significantly higher levels of matrix metallopeptidase 9 (MMP9) and transforming growth factor, beta receptor 1 (TGFBR1). MMP14 was lower in VUE than CHI (p < 0.05) and controls (not significant). Chemokine (C-X-C motif) ligand 9 (CXCL9), CXCL12, chemokine (C-C motif) ligand 5 (CCL5) and TIMP metallopeptidase inhibitor 1 (TIMP1) were significantly higher in VUE versus controls but not deregulated in CHI. The expression profile could not clearly discriminate CHI from VUE or controls but a tendency for grouping of massive CHI was found. Angiogenesis-associated factors were not deregulated in CHI. CONCLUSION: The discrepancy of massive histiocytic accumulation and the lack of striking up-regulation of cytokines might be the basis of the non-destructive behaviour of the histiocytes in CHI.
Authors: A Pilatz; B Altinkilic; A Rusz; N Izykowski; W Traenkenschuh; J Rische; U Lehmann; C Herbst; L Maegel; J Becker; W Weidner; D Jonigk Journal: J Eur Acad Dermatol Venereol Date: 2012-04-04 Impact factor: 6.166
Authors: Hillary Hosier; Shelli F Farhadian; Raffaella A Morotti; Uma Deshmukh; Alice Lu-Culligan; Katherine H Campbell; Yuki Yasumoto; Chantal Bf Vogels; Arnau Casanovas-Massana; Pavithra Vijayakumar; Bertie Geng; Camila D Odio; John Fournier; Anderson F Brito; Joseph R Fauver; Feimei Liu; Tara Alpert; Reshef Tal; Klara Szigeti-Buck; Sudhir Perincheri; Christopher Larsen; Aileen M Gariepy; Gabriela Aguilar; Kristen L Fardelmann; Malini Harigopal; Hugh S Taylor; Christian M Pettker; Anne L Wyllie; Charles Dela Cruz; Aaron M Ring; Nathan D Grubaugh; Albert I Ko; Tamas L Horvath; Akiko Iwasaki; Uma M Reddy; Heather S Lipkind Journal: J Clin Invest Date: 2020-09-01 Impact factor: 14.808
Authors: Theodora-Eleftheria Deftereou; Anna Trypidi; Christina Angelika Alexiadi; Paschalis Theotokis; Maria Eleni Manthou; Soultana Meditskou; Maria Simopoulou; Maria Lambropoulou Journal: Cureus Date: 2022-09-13