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Literature DB >> 23695288

Secondary variants--in defense of a more fitting term in the incidental findings debate.

Gabrielle M Christenhusz¹, Koenraad Devriendt, Kris Dierickx.

Abstract

New genetic technologies are capable of returning far more information than the single answer to the single question posed when conducting a given genetic test. Genetics contexts consequently stand on the brink of an explosion of what have traditionally been called 'incidental findings'. However, the continued use of this term is controversial. Various replacements for 'incidental findings' have been attempted, but none with widespread success. Agreement on terminology and definitions is vital so that the legal and ethical debate around incidental findings can proceed. We highlight the difficulties raised by the various terms currently used as alternatives, and end by defending our choice for the term 'secondary variants'.

Mesh：

Year: 2013 PMID： 23695288 PMCID： PMC3831086 DOI： 10.1038/ejhg.2013.89

Source DB: PubMed Journal: Eur J Hum Genet ISSN： 1018-4813 Impact factor: 4.246

32 in total

Review 1. Personal view: 'don't ask, don't tell'--the undesirable consequences of incidental test results in gastroenterology.

Authors: A Sonnenberg
Journal: Aliment Pharmacol Ther Date: 2004-08-15 Impact factor: 8.171

Review 2. Observation and cogitation: how serendipity provides the building blocks of scientific discovery.

Authors: M K Stoskopf
Journal: ILAR J Date: 2005

3. Incidentalomas--clinical correlation and translational science required.

Authors: John H Stone
Journal: N Engl J Med Date: 2006-06-29 Impact factor: 91.245

4. Subjects' expectations in neuroimaging research.

Authors: Matthew P Kirschen; Agnieszka Jaworska; Judy Illes
Journal: J Magn Reson Imaging Date: 2006-02 Impact factor: 4.813

5. Ethical considerations in the communication of unexpected information with clinical implications.

Authors: Robert R Lavieri; Samual A Garner
Journal: Am J Bioeth Date: 2006 Nov-Dec Impact factor: 11.229

6. Disclosing individual genetic results to research participants.

Authors: Vardit Ravitsky; Benjamin S Wilfond
Journal: Am J Bioeth Date: 2006 Nov-Dec Impact factor: 11.229

7. Extending the scope of diagnostic chromosome analysis: detection of single gene defects using high-resolution SNP microarrays.

Authors: Damien L Bruno; Zornitza Stark; David J Amor; Trent Burgess; Kathy Butler; Sylvea Corrie; David Francis; Devika Ganesamoorthy; Louise Hills; Paul A James; Darren O'Rielly; Ralph Oertel; Ravi Savarirayan; Krishnamurthy Prabhakara; Nicholas Salce; Howard R Slater
Journal: Hum Mutat Date: 2011-09-19 Impact factor: 4.878

8. Benign anatomical mistakes: incidentaloma.

Authors: Petros Mirilas; J E Skandalakis
Journal: Am Surg Date: 2002-11 Impact factor: 0.688

9. The emergence of an ethical duty to disclose genetic research results: international perspectives.

Authors: Bartha Maria Knoppers; Yann Joly; Jacques Simard; Francine Durocher
Journal: Eur J Hum Genet Date: 2006-07-26 Impact factor: 4.246

Review 10. Educating the general public about multifactorial genetic disease: applying a theory-based framework to understand current public knowledge.

Authors: Chris M R Smerecnik; Ilse Mesters; Nanne K de Vries; Hein de Vries
Journal: Genet Med Date: 2008-04 Impact factor: 8.822

13 in total

1. Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing.

Authors: Elli G Gourna; Natalie Armstrong; Susan E Wallace
Journal: Eur J Hum Genet Date: 2015-06-10 Impact factor: 4.246

Secondary variants--in defense of a more fitting term in the incidental findings debate.

Review 1. Personal view: 'don't ask, don't tell'--the undesirable consequences of incidental test results in gastroenterology.

Review 2. Observation and cogitation: how serendipity provides the building blocks of scientific discovery.

3. Incidentalomas--clinical correlation and translational science required.

4. Subjects' expectations in neuroimaging research.

5. Ethical considerations in the communication of unexpected information with clinical implications.

6. Disclosing individual genetic results to research participants.

7. Extending the scope of diagnostic chromosome analysis: detection of single gene defects using high-resolution SNP microarrays.

8. Benign anatomical mistakes: incidentaloma.

9. The emergence of an ethical duty to disclose genetic research results: international perspectives.

Review 10. Educating the general public about multifactorial genetic disease: applying a theory-based framework to understand current public knowledge.

1. Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing.

2. Ethical signposts for clinical geneticists in secondary variant and incidental finding disclosure discussions.

3. Incidental or secondary findings: an integrative and patient-inclusive approach to the current debate.

4. Points to consider for laboratories reporting results from diagnostic genomic sequencing.

5. A framework for analyzing the ethics of disclosing genetic research findings.

6. Effect of Public Deliberation on Attitudes toward Return of Secondary Results in Genomic Sequencing.

7. The unintended implications of blurring the line between research and clinical care in a genomic age.

Review 8. Genome-Wide Sequencing for Prenatal Detection of Fetal Single-Gene Disorders.

9. A more fitting term in the incidental findings debate: one term does not fit all situations.

Review 10. Incidental Findings with Genomic Testing: Implications for Genetic Counseling Practice.