BACKGROUND: The aim of this study was to investigate the association between the occurrence of acute kidney injury (AKI) according to pediatric RIFLE (pRIFLE) criteria and adverse outcomes in children after heart surgery. METHODS: Children undergoing heart surgery in a tertiary hospital in Southern Brazil were followed during their stay in the pediatric intensive care unit (PICU) or until death. The exposure variable was occurrence of AKI according to pRIFLE criteria which place AKI in three categories: R (risk), I (injury), and F (failure). The outcomes studied were death, length of mechanical ventilation (MV), and length of PICU stay. RESULTS: Eighty-five children were enrolled in the study. Of these, 47 (55.3 %) did not have AKI, while 22 (25.9 %), seven (8.2 %), and nine (10.6 %) were classified into pRIFLE categories R, I, and F, respectively. The incidence of death was 18.4 and 4.2 % in patients with and without AKI, respectively. Compared to children who did not develop AKI, the adjusted odds ratio for death was 1.05 [95 % confidence interval (CI) 0.09-11.11], 8.36 (95 % CI 1.32-52.63), and 7.85 (95 % CI 1.53-40.29) in the R, I, and F groups, respectively (p = 0.022). Duration of MV and of PICU stay were significantly higher in those children with AKI. CONCLUSIONS: The occurrence of AKI according to pRIFLE criteria is associated to adverse outcomes in children after heart surgery.
BACKGROUND: The aim of this study was to investigate the association between the occurrence of acute kidney injury (AKI) according to pediatric RIFLE (pRIFLE) criteria and adverse outcomes in children after heart surgery. METHODS:Children undergoing heart surgery in a tertiary hospital in Southern Brazil were followed during their stay in the pediatric intensive care unit (PICU) or until death. The exposure variable was occurrence of AKI according to pRIFLE criteria which place AKI in three categories: R (risk), I (injury), and F (failure). The outcomes studied were death, length of mechanical ventilation (MV), and length of PICU stay. RESULTS: Eighty-five children were enrolled in the study. Of these, 47 (55.3 %) did not have AKI, while 22 (25.9 %), seven (8.2 %), and nine (10.6 %) were classified into pRIFLE categories R, I, and F, respectively. The incidence of death was 18.4 and 4.2 % in patients with and without AKI, respectively. Compared to children who did not develop AKI, the adjusted odds ratio for death was 1.05 [95 % confidence interval (CI) 0.09-11.11], 8.36 (95 % CI 1.32-52.63), and 7.85 (95 % CI 1.53-40.29) in the R, I, and F groups, respectively (p = 0.022). Duration of MV and of PICU stay were significantly higher in those children with AKI. CONCLUSIONS: The occurrence of AKI according to pRIFLE criteria is associated to adverse outcomes in children after heart surgery.
Authors: J E Kist-van Holthe tot Echten; C A Goedvolk; M B Doornaar; M M van der Vorst; J M Bosman-Vermeeren; R Brand; A J van der Heijden; P H Schoof; M G Hazekamp Journal: Pediatr Cardiol Date: 2001 Jul-Aug Impact factor: 1.655
Authors: Michael Zappitelli; Pierre-Luc Bernier; Richard S Saczkowski; Christo I Tchervenkov; Ronald Gottesman; Adrian Dancea; Ayaz Hyder; Omar Alkandari Journal: Kidney Int Date: 2009-07-29 Impact factor: 10.612
Authors: K R Pedersen; J V Povlsen; S Christensen; J Pedersen; K Hjortholm; S H Larsen; V E Hjortdal Journal: Acta Anaesthesiol Scand Date: 2007-11 Impact factor: 2.105
Authors: Emily M Bucholz; Richard P Whitlock; Michael Zappitelli; Prasad Devarajan; John Eikelboom; Amit X Garg; Heather Thiessen Philbrook; Philip J Devereaux; Catherine D Krawczeski; Peter Kavsak; Colleen Shortt; Chirag R Parikh Journal: Pediatrics Date: 2015-03-09 Impact factor: 7.124
Authors: Maite Augusta Gil-Ruiz Gil-Esparza; Andrés José Alcaraz Romero; Alfonso Romero Otero; Nuria Gil Villanueva; Eva Sanavia Morán; Ana Rodríguez Sánchez de la Blanca; Jorge Lorente Romero; José María Bellón Cano Journal: Pediatr Nephrol Date: 2014-02-05 Impact factor: 3.714
Authors: Shahram Amini; Hasan Abbaspour; Negar Morovatdar; Hojat Naghavi Robabi; Ghasem Soltani; Mohammad Abbasi Tashnizi Journal: Indian J Crit Care Med Date: 2017-12