| Literature DB >> 23689382 |
T J G Chambers1, A Giles, G Brabant, J R E Davis.
Abstract
Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.Entities:
Keywords: Wnt; adenoma; development; pituitary; tumorigenesis
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Year: 2013 PMID: 23689382 DOI: 10.1530/ERC-13-0005
Source DB: PubMed Journal: Endocr Relat Cancer ISSN: 1351-0088 Impact factor: 5.678