Bozena Coha1, Ivana Vucinic2, Ivana Mahovne3, Zeljka Vukovic-Arar4. 1. Department of Internal Medicine (Head: Samardzic Pejo, MD), General Hospital "Dr. Josip Bencevic", A. Stampara 42, 35000 Slavonski Brod, Croatia. Electronic address: bozena.coha@sb.t-com.hr. 2. Department of Internal Medicine (Head: Samardzic Pejo, MD), General Hospital "Dr. Josip Bencevic", A. Stampara 42, 35000 Slavonski Brod, Croatia. 3. Department of Pathology (Head: Jakovina Krunoslav, MD), General Hospital "Dr. Josip Bencevic", Slavonski Brod, Croatia. 4. Department of Ophthalmology (Head: Janjetovic Zeljka, MD), General Hospital "Dr. Josip Bencevic", Slavonski Brod, Croatia.
Abstract
PURPOSE: To determine the occurrence, clinical course and outcome of our patients with natural killer/T-cell lymphoma (NKTCL), nasal type. The nasal type of natural killer/T-cell lymphoma (NKTCL), is rare in the European population but is more frequent in Asia, Central and South America where it accounts for 15-20% of all non-Hodgkin lymphomas (NHL). This type of lymphoma is characterized by tissue necrosis and destruction of the nasal cavity and upper aero-digestive tract. The disease is closely associated with Epstein-Barr virus (EBV) infection and has an aggressive clinical course, poor clinical outcome and high resistance to chemotherapy. PATIENTS: 63 patients with NHL were treated in our department between 2006 and 2011. Eleven patients were diagnosed with extranodal lymphoma, 6 in the area of head and neck. Three of them belonged to NKTCL, nasal type group (4.7%), 1 was diffuse large B cell lymphoma and 2 were marginal zone lymphomas. CONCLUSION: Two out of 3 patients with nasal type NKTCL, had extremely aggressive disease resistant to applied chemotherapy (anthracycline containing regimen), while 1 patient remains in complete remission 6 years after diagnosis.
PURPOSE: To determine the occurrence, clinical course and outcome of our patients with natural killer/T-cell lymphoma (NKTCL), nasal type. The nasal type of natural killer/T-cell lymphoma (NKTCL), is rare in the European population but is more frequent in Asia, Central and South America where it accounts for 15-20% of all non-Hodgkin lymphomas (NHL). This type of lymphoma is characterized by tissue necrosis and destruction of the nasal cavity and upper aero-digestive tract. The disease is closely associated with Epstein-Barr virus (EBV) infection and has an aggressive clinical course, poor clinical outcome and high resistance to chemotherapy. PATIENTS: 63 patients with NHL were treated in our department between 2006 and 2011. Eleven patients were diagnosed with extranodal lymphoma, 6 in the area of head and neck. Three of them belonged to NKTCL, nasal type group (4.7%), 1 was diffuse large B cell lymphoma and 2 were marginal zone lymphomas. CONCLUSION: Two out of 3 patients with nasal type NKTCL, had extremely aggressive disease resistant to applied chemotherapy (anthracycline containing regimen), while 1 patient remains in complete remission 6 years after diagnosis.
Authors: Grażyna Lisowska; Natalia Zięba; Grażyna Stryjewska-Makuch; Wojciech Ścierski; Katarzyna Miśkiewicz-Orczyk; Maciej Misiołek Journal: Am J Case Rep Date: 2020-09-21