W McBride1, J D Jackman, P A Grayburn. 1. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Abstract
PURPOSE: This study was undertaken to define the prevalence and clinical characteristics of patients with a high cardiac output state associated with multiple myeloma. PATIENTS AND METHODS: Specifically, we evaluated clinical, laboratory, and two-dimensional and Doppler echocardiographic data in 36 patients with multiple myeloma. Cardiac output was determined noninvasively by a pulsed Doppler technique. RESULTS: A high cardiac output state, defined as a cardiac index greater than or equal to 4.0 L/minute/m2, was present in eight of 34 (23.5%) subjects in whom cardiac output was measurable. None of the known causes of high output states could be identified in these patients. Four patients developed high output congestive heart failure, two of whom died. Age, sex, degree of anemia, serum calcium level, immunoglobulin type, or disease stage did not differ significantly between subjects with or without high output states. However, severe bone involvement was significantly more frequent in those patients with high cardiac output states, occurring in all eight patients with high cardiac indexes compared with nine of 26 patients with low or normal cardiac indexes (p = 0.001). CONCLUSION: These data demonstrate that high cardiac output states are relatively common in patients with multiple myeloma and are associated with the presence of extensive bone disease.
PURPOSE: This study was undertaken to define the prevalence and clinical characteristics of patients with a high cardiac output state associated with multiple myeloma. PATIENTS AND METHODS: Specifically, we evaluated clinical, laboratory, and two-dimensional and Doppler echocardiographic data in 36 patients with multiple myeloma. Cardiac output was determined noninvasively by a pulsed Doppler technique. RESULTS: A high cardiac output state, defined as a cardiac index greater than or equal to 4.0 L/minute/m2, was present in eight of 34 (23.5%) subjects in whom cardiac output was measurable. None of the known causes of high output states could be identified in these patients. Four patients developed high output congestive heart failure, two of whom died. Age, sex, degree of anemia, serum calcium level, immunoglobulin type, or disease stage did not differ significantly between subjects with or without high output states. However, severe bone involvement was significantly more frequent in those patients with high cardiac output states, occurring in all eight patients with high cardiac indexes compared with nine of 26 patients with low or normal cardiac indexes (p = 0.001). CONCLUSION: These data demonstrate that high cardiac output states are relatively common in patients with multiple myeloma and are associated with the presence of extensive bone disease.
Authors: Mohamad Hemu; Caleb J Chiang; Parva K Bhatt; Aamir Ahmed; Kyaw Zaw Hein; Talal Mourad; Megan E Randall; Andres P Palomo; Jason B Kramer; Ibtihaj Fughhi; Louis Fogg; Philip Bonomi; Tochukwu M Okwuosa Journal: J Thorac Dis Date: 2021-08 Impact factor: 2.895
Authors: Driss Chaoui; Bruno Gallet; Philippe Genet; Babette Mbungani; Ahmad Al Jijakli; Nina Arakelyan; Louisa Mesbah; Laurent Sutton Journal: Case Rep Hematol Date: 2013-03-04