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Literature DB >> 23687657

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.

Louise E Wedlock¹, Matt R Kilburn, Rong Liu, Jeremy A Shaw, Susan J Berners-Price, Nicholas P Farrell.

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 23687657 PMCID： PMC4132055 DOI： 10.1039/c3cc42098a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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