BACKGROUND:Endoscopists with extensive experience withconfocal endomicroscopy (CEM) have demonstrated that this technology is useful for Barrett's esophagus (BE) surveillance. However, data on endoscopists with minimal experience with this technique are limited. HYPOTHESIS: For BE surveillance, an endoscopist with minimal experience in CEM-guided biopsy would achieve a similar diagnostic yield with fewer biopsies when compared to the random 4-quadrant biopsy protocol. OBJECTIVE: To compare the diagnostic yields of CEM-guided biopsy technique with the random 4-quadrant biopsy protocol. DESIGN: Randomized controlled trial. SETTING: Tertiary care center. PATIENTS: Patients with BE. METHODS: Out of 18 patients who underwent routine BE surveillance, 11 and 7 were randomly assigned to group A (CEM-guided) and to group B (random 4-quadrant biopsy), respectively. The pathologists were blinded to all clinical information. RESULTS:Mean length of endoscopic Barrett was similar in both groups, (5.1 vs. 6.3 cm, p=0.51). The diagnostic yields for detecting SIM (63.6% vs. 59.5%, p=0.5), low grade dysplasia (11. 6% vs. 11.2%, p=NS), high grade dysplasia (10.1% vs. 11.5%, p=0.88). Although the total number of individual mucosal biopsy performed were 52% lower in the CEM group (129 vs. 269), the overall diagnostic yield (85.3% vs. 82.2%, p=0.53) was similar in both groups. LIMITATIONS: Small sample size. CONCLUSIONS: For BE surveillance, limited data suggested that endoscopists with minimal experience in CEM can effective use this technology for "smart" biopsy to decrease the need for intense tissue sampling but without lowering the diagnostic yield in detecting dysplasia.
RCT Entities:
BACKGROUND: Endoscopists with extensive experience with confocal endomicroscopy (CEM) have demonstrated that this technology is useful for Barrett's esophagus (BE) surveillance. However, data on endoscopists with minimal experience with this technique are limited. HYPOTHESIS: For BE surveillance, an endoscopist with minimal experience in CEM-guided biopsy would achieve a similar diagnostic yield with fewer biopsies when compared to the random 4-quadrant biopsy protocol. OBJECTIVE: To compare the diagnostic yields of CEM-guided biopsy technique with the random 4-quadrant biopsy protocol. DESIGN: Randomized controlled trial. SETTING: Tertiary care center. PATIENTS: Patients with BE. METHODS: Out of 18 patients who underwent routine BE surveillance, 11 and 7 were randomly assigned to group A (CEM-guided) and to group B (random 4-quadrant biopsy), respectively. The pathologists were blinded to all clinical information. RESULTS: Mean length of endoscopic Barrett was similar in both groups, (5.1 vs. 6.3 cm, p=0.51). The diagnostic yields for detecting SIM (63.6% vs. 59.5%, p=0.5), low grade dysplasia (11. 6% vs. 11.2%, p=NS), high grade dysplasia (10.1% vs. 11.5%, p=0.88). Although the total number of individual mucosal biopsy performed were 52% lower in the CEM group (129 vs. 269), the overall diagnostic yield (85.3% vs. 82.2%, p=0.53) was similar in both groups. LIMITATIONS: Small sample size. CONCLUSIONS: For BE surveillance, limited data suggested that endoscopists with minimal experience in CEM can effective use this technology for "smart" biopsy to decrease the need for intense tissue sampling but without lowering the diagnostic yield in detecting dysplasia.
Authors: Ralf Kiesslich; Liebwin Gossner; Martin Goetz; Alexandra Dahlmann; Michael Vieth; Manfred Stolte; Arthur Hoffman; Michael Jung; Bernhard Nafe; Peter R Galle; Markus F Neurath Journal: Clin Gastroenterol Hepatol Date: 2006-07-13 Impact factor: 11.382
Authors: Wouter L Curvers; Frank J C van den Broek; Johannes B Reitsma; Evelien Dekker; Jacques J G H M Bergman Journal: Gastrointest Endosc Date: 2009-02 Impact factor: 9.427
Authors: Ralf Kiesslich; Martin Goetz; Katharina Lammersdorf; Constantin Schneider; Juergen Burg; Manfred Stolte; Michael Vieth; Bernhard Nafe; Peter R Galle; Markus F Neurath Journal: Gastroenterology Date: 2007-01-31 Impact factor: 22.682
Authors: Alessandro Fugazza; Federica Gaiani; Maria Clotilde Carra; Francesco Brunetti; Michaël Lévy; Iradj Sobhani; Daniel Azoulay; Fausto Catena; Gian Luigi de'Angelis; Nicola de'Angelis Journal: Biomed Res Int Date: 2016-02-17 Impact factor: 3.411