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Literature DB >> 23684893

Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.

Michitaka Yamaguchi¹, Mitsue Miyazaki, Matthew P Kodrasov, Henki Rotinsulu, Fitje Losung, Remy E P Mangindaan, Nicole J de Voogd, Hideyoshi Yokosawa, Benjamin Nicholson, Sachiko Tsukamoto.

Abstract

USP7, a deubiquitylating enzyme hydrolyzing the isopeptide bond at the C-terminus of ubiquitin, is an emerging cancer target. We isolated spongiacidin C from the marine sponge Stylissa massa as the first USP7 inhibitor from a natural source. This compound inhibited USP7 most strongly with an IC50 of 3.8 μM among several USP family members tested.

Entities: Chemical Disease Species

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Year: 2013 PMID： 23684893 DOI： 10.1016/j.bmcl.2013.04.066

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

20 in total

Review 1. Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.

Authors: Key-Hwan Lim; Myoung-Hyun Song; Kwang-Hyun Baek
Journal: Cell Mol Life Sci Date: 2016-01-13 Impact factor: 9.261

2. Ceylonins G-I: spongian diterpenes from the marine sponge Spongia ceylonensis.

Authors: Ahmed H El-Desoky; Hikaru Kato; Sachiko Tsukamoto
Journal: J Nat Med Date: 2017-05-03 Impact factor: 2.343

Review 3. Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.

Authors: Anthony Scott; Jing Song; Rob Ewing; Zhenghe Wang
Journal: Acta Biochim Biophys Sin (Shanghai) Date: 2014-01-03 Impact factor: 3.848

4. Composition and Predictive Functional Analysis of Bacterial Communities in Seawater, Sediment and Sponges in the Spermonde Archipelago, Indonesia.

Authors: Daniel F R Cleary; Nicole J de Voogd; Ana R M Polónia; Rossana Freitas; Newton C M Gomes
Journal: Microb Ecol Date: 2015-06-14 Impact factor: 4.552

5. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Authors: Ilaria Lamberto; Xiaoxi Liu; Hyuk-Soo Seo; Nathan J Schauer; Roxana E Iacob; Wanyi Hu; Deepika Das; Tatiana Mikhailova; Ellen L Weisberg; John R Engen; Kenneth C Anderson; Dharminder Chauhan; Sirano Dhe-Paganon; Sara J Buhrlage
Journal: Cell Chem Biol Date: 2017-10-19 Impact factor: 8.116

6. Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Authors: Andrew P Turnbull; Stephanos Ioannidis; Wojciech W Krajewski; Adan Pinto-Fernandez; Claire Heride; Agnes C L Martin; Louise M Tonkin; Elizabeth C Townsend; Shane M Buker; David R Lancia; Justin A Caravella; Angela V Toms; Thomas M Charlton; Johanna Lahdenranta; Erik Wilker; Bruce C Follows; Nicola J Evans; Lucy Stead; Cristina Alli; Vladislav V Zarayskiy; Adam C Talbot; Alexandre J Buckmelter; Minghua Wang; Crystal L McKinnon; Fabienne Saab; Joanna F McGouran; Hannah Century; Malte Gersch; Marc S Pittman; C Gary Marshall; Tony M Raynham; Mary Simcox; Lorna M D Stewart; Sheila B McLoughlin; Jaime A Escobedo; Kenneth W Bair; Christopher J Dinsmore; Tim R Hammonds; Sunkyu Kim; Sylvie Urbé; Michael J Clague; Benedikt M Kessler; David Komander
Journal: Nature Date: 2017-10-18 Impact factor: 49.962

Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.

Review 1. Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.

2. Ceylonins G-I: spongian diterpenes from the marine sponge Spongia ceylonensis.

Review 3. Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.

4. Composition and Predictive Functional Analysis of Bacterial Communities in Seawater, Sediment and Sponges in the Spermonde Archipelago, Indonesia.

5. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

6. Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Review 7. Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors.

Review 8. Deubiquitinases and the new therapeutic opportunities offered to cancer.

Review 9. Cell death and deubiquitinases: perspectives in cancer.

Review 10. Marine low molecular weight natural products as potential cancer preventive compounds.