Literature DB >> 23682352

Locked nucleic acid: tighter is different.

Jonathan K Watts1.   

Abstract

This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.

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Year:  2013        PMID： 23682352     DOI： 10.1039/c3cc40340h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

Review 1.  The chemical evolution of oligonucleotide therapies of clinical utility.

Authors:  Anastasia Khvorova; Jonathan K Watts
Journal:  Nat Biotechnol       Date:  2017-02-27       Impact factor: 54.908

2.  Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

Authors:  Pawan Kumar; Afaf H El-Sagheer; Lynda Truong; Tom Brown
Journal:  Chem Commun (Camb)       Date:  2017-08-03       Impact factor: 6.222

3.  Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy.

Authors:  Jiaxin Hu; Ziye Rong; Xin Gong; Zhengyang Zhou; Vivek K Sharma; Chao Xing; Jonathan K Watts; David R Corey; V Vinod Mootha
Journal:  Hum Mol Genet       Date:  2018-03-15       Impact factor: 6.150

Review 4.  Synthesis of Spironucleosides: Past and Future Perspectives.

Authors:  Raquel G Soengas; Gustavo da Silva; Juan Carlos Estévez
Journal:  Molecules       Date:  2017-11-22       Impact factor: 4.411

Review 5.  Enhanced Inhibition of Tumorigenesis Using Combinations of miRNA-Targeted Therapeutics.

Authors:  Svetlana Miroshnichenko; Olga Patutina
Journal:  Front Pharmacol       Date:  2019-05-16       Impact factor: 5.988

Review 6.  Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications.

Authors:  Daniela Perrone; Elena Marchesi; Lorenzo Preti; Maria Luisa Navacchia
Journal:  Molecules       Date:  2021-05-22       Impact factor: 4.411

7.  Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions.

Authors:  Sung-Kun Kim; Aaron Castro; Edward S Kim; Austin P Dinkel; Xiaoyun Liu; Miguel Castro
Journal:  PLoS One       Date:  2016-01-28       Impact factor: 3.240

Review 8.  Deciphering Non-coding RNAs in Cardiovascular Health and Disease.

Authors:  Anindita Das; Arun Samidurai; Fadi N Salloum
Journal:  Front Cardiovasc Med       Date:  2018-07-02

9.  Synthesis and antiviral properties of spirocyclic [1,2,3]-triazolooxazine nucleosides.

Authors:  Antonio Dell'Isola; Matthew M W McLachlan; Benjamin W Neuman; Hawaa M N Al-Mullah; Alexander W D Binks; Warren Elvidge; Kenneth Shankland; Alexander J A Cobb
Journal:  Chemistry       Date:  2014-07-31       Impact factor: 5.236

10.  Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.

Authors:  Hannah M Pendergraff; Pranathi Meda Krishnamurthy; Alexandre J Debacker; Michael P Moazami; Vivek K Sharma; Liisa Niitsoo; Yong Yu; Yen Nee Tan; Hans Michael Haitchi; Jonathan K Watts
Journal:  Mol Ther Nucleic Acids       Date:  2017-06-21       Impact factor: 10.183
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