| Literature DB >> 23673648 |
Lara Spinner1, Astrid Gadeyne, Katia Belcram, Magali Goussot, Michaël Moison, Yann Duroc, Dominique Eeckhout, Nancy De Winne, Estelle Schaefer, Eveline Van De Slijke, Geert Persiau, Erwin Witters, Kris Gevaert, Geert De Jaeger, David Bouchez, Daniël Van Damme, Martine Pastuglia.
Abstract
In the absence of cell migration, the orientation of cell divisions is crucial for body plan determination in plants. The position of the division plane in plant cells is set up premitotically via a transient cytoskeletal array, the preprophase band, which precisely delineates the cortical plane of division. Here we describe a protein complex that targets protein phosphatase 2A activity to microtubules, regulating the transition from the interphase to the premitotic microtubule array. This complex, which comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins. Despite the acentrosomal nature of plant cells, all members of this complex share similarity with animal centrosomal proteins involved in ciliary and centriolar/centrosomal functions, revealing an evolutionary link between the cortical cytoskeleton of plant cells and microtubule organizers in other eukaryotes.Entities:
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Year: 2013 PMID： 23673648 DOI： 10.1038/ncomms2831
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919