| Literature DB >> 32364331 |
Xingwu Zhou1,2,3, Zhimin Luo1,2,4, Avijit Baidya1,2, Han-Jun Kim1,2, Canran Wang1,2, Xing Jiang1,2,5, Moyuan Qu1,2,6, Jixiang Zhu1,2,7, Li Ren1,2, Fereshteh Vajhadin1,2,8, Peyton Tebon1,2, Niyuan Zhang1,2, Yumeng Xue1,2, Yudi Feng1,2, Chengbin Xue1,2, Yi Chen1,2, KangJu Lee1,2, Junmin Lee1,2, Shiming Zhang1,2, Chun Xu1,2,9, Nureddin Ashammakhi1,2,10, Samad Ahadian1,2,10,11, Mehmet Remzi Dokmeci1,2,10,11, Zhen Gu1,2,12, Wujin Sun1,2, Ali Khademhosseini1,2,3,10,11,12.
Abstract
Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.Entities:
Keywords: gelatin methacryloyl; microneedles; transdermal delivery; water insoluble drugs; β-cyclodextrin
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Year: 2020 PMID： 32364331 PMCID： PMC7462883 DOI： 10.1002/adhm.202000527
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933