OBJECTIVES: To determine if extensive upper abdominal surgery (UAS) affected overall survival (OS) in patients left with ≤ 1 cm but visible residual disease after undergoing primary cytoreductive surgery for ovarian cancer. Our secondary objective was to determine if leaving ≤ 1cm but visible residual throughout the small bowel (SB) conferred a worse prognosis. METHODS: All stage IIIB-IV ovarian cancer patients who had visible but ≤ 1 cm residual disease at time of primary cytoreductive surgery from 2001 to 2010 were identified. Extensive UAS procedures and residual SB involvement were recorded. RESULTS: The 219 patients identified with ≤1 cm but visible residual disease had a median OS of 51 months. In this cohort, 127 had extensive UAS performed, and 87 had residual disease involving the SB. Univariate OS analysis was performed. There was no significant difference in OS between patients who did or did not have extensive UAS (45 vs. 52 months, P=0.56), or between patients with or without residual SB disease (45 vs. 51 months, P=0.84). Factors that were significantly associated with OS were age, ASA score, family history, and stage. CONCLUSIONS: Patients cytoreduced to ≤ 1 cm but visible residual disease who required UAS did not have a worse OS than those who did not require UAS. OS was similar if residual disease involved the SB or not. For ovarian cancer patients with disease not amenable to complete gross resection, extensive surgery should still be considered to achieve ≤ 1 cm but visible residual disease status, including cases where the residual disease involves the SB.
OBJECTIVES: To determine if extensive upper abdominal surgery (UAS) affected overall survival (OS) in patients left with ≤ 1 cm but visible residual disease after undergoing primary cytoreductive surgery for ovarian cancer. Our secondary objective was to determine if leaving ≤ 1cm but visible residual throughout the small bowel (SB) conferred a worse prognosis. METHODS: All stage IIIB-IV ovarian cancerpatients who had visible but ≤ 1 cm residual disease at time of primary cytoreductive surgery from 2001 to 2010 were identified. Extensive UAS procedures and residual SB involvement were recorded. RESULTS: The 219 patients identified with ≤1 cm but visible residual disease had a median OS of 51 months. In this cohort, 127 had extensive UAS performed, and 87 had residual disease involving the SB. Univariate OS analysis was performed. There was no significant difference in OS between patients who did or did not have extensive UAS (45 vs. 52 months, P=0.56), or between patients with or without residual SB disease (45 vs. 51 months, P=0.84). Factors that were significantly associated with OS were age, ASA score, family history, and stage. CONCLUSIONS:Patients cytoreduced to ≤ 1 cm but visible residual disease who required UAS did not have a worse OS than those who did not require UAS. OS was similar if residual disease involved the SB or not. For ovarian cancerpatients with disease not amenable to complete gross resection, extensive surgery should still be considered to achieve ≤ 1 cm but visible residual disease status, including cases where the residual disease involves the SB.
Authors: Neil S Horowitz; G Larry Maxwell; Austin Miller; Chad A Hamilton; Bunja Rungruang; Noah Rodriguez; Scott D Richard; Thomas C Krivak; Jeffrey M Fowler; David G Mutch; Linda Van Le; Roger B Lee; Peter Argenta; David Bender; Krishnansu S Tewari; David Gershenson; James J Java; Michael A Bookman Journal: Gynecol Oncol Date: 2017-11-23 Impact factor: 5.482
Authors: Fanny Dao; Brooke A Schlappe; Jill Tseng; Jenny Lester; Alpa M Nick; Susan K Lutgendorf; Scott McMeekin; Robert L Coleman; Kathleen N Moore; Beth Y Karlan; Anil K Sood; Douglas A Levine Journal: Gynecol Oncol Date: 2016-03-11 Impact factor: 5.482
Authors: Jennifer J Mueller; Amelia Kelly; Qin Zhou; Alexia Iasonos; Kara Long Roche; Yukio Sonoda; Roisin E O'Cearbhaill; Oliver Zivanovic; Dennis S Chi; Ginger J Gardner Journal: Gynecol Oncol Date: 2016-09-28 Impact factor: 5.482
Authors: Florian Finkernagel; Silke Reinartz; Maximiliane Schuldner; Alexandra Malz; Julia M Jansen; Uwe Wagner; Thomas Worzfeld; Johannes Graumann; Elke Pogge von Strandmann; Rolf Müller Journal: Theranostics Date: 2019-08-22 Impact factor: 11.556