Literature DB >> 23671815

Genetic instability of modified stem cells - a first step towards malignant transformation?

Doris Steinemann1, Gudrun Göhring, Brigitte Schlegelberger.   

Abstract

Induced pluripotent stem cells (iPSC) are important tools in regenerative medicine. Yet, it is becoming increasingly clear that the reprogramming process, including retroviral transduction with potent oncogenes like c-Myc and long-term cultivation, may induce genetic instability. Genetically altered iPS cells can grow out and dominate the cell culture. This review intends to comprehensively summarize the current knowledge on genetic instability of embryonic and iPSCs, with an emphasis on cytogenetic alterations, and compares these data with what is known from tumorigenesis.

Entities:  

Keywords:  Induced pluripotent stem cells; P53; chromosomal instability; chromosome; clonal evolution; gene therapy; genetic integrity; leukemia; mutation; tumor

Year:  2013        PMID： 23671815      PMCID： PMC3636728     

Source DB:  PubMed          Journal:  Am J Stem Cells        ISSN： 2160-4150


  59 in total

1.  iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability.

Authors:  Veronica Ramos-Mejia; Martin Muñoz-Lopez; Jose L Garcia-Perez; Pablo Menendez
Journal:  Cell Res       Date:  2010-09-07       Impact factor: 25.617

2.  Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells.

Authors:  Uri Ben-David; Yoav Mayshar; Nissim Benvenisty
Journal:  Cell Stem Cell       Date:  2011-08-05       Impact factor: 24.633

3.  Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression.

Authors:  Linzhao Cheng; Nancy F Hansen; Ling Zhao; Yutao Du; Chunlin Zou; Frank X Donovan; Bin-Kuan Chou; Guangyu Zhou; Shijie Li; Sarah N Dowey; Zhaohui Ye; Settara C Chandrasekharappa; Huanming Yang; James C Mullikin; P Paul Liu
Journal:  Cell Stem Cell       Date:  2012-03-02       Impact factor: 24.633

4.  Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming.

Authors:  Aaron R Quinlan; Michael J Boland; Mitchell L Leibowitz; Svetlana Shumilina; Sidney M Pehrson; Kristin K Baldwin; Ira M Hall
Journal:  Cell Stem Cell       Date:  2011-10-04       Impact factor: 24.633

5.  Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

Authors:  Hyenjong Hong; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Osami Kanagawa; Masato Nakagawa; Keisuke Okita; Shinya Yamanaka
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

6.  MiR-138 promotes induced pluripotent stem cell generation through the regulation of the p53 signaling.

Authors:  Dan Ye; Guiying Wang; Yang Liu; Wenfei Huang; Minjuan Wu; Songcheng Zhu; Wenwen Jia; An-Mei Deng; Houqi Liu; Jiuhong Kang
Journal:  Stem Cells       Date:  2012-08       Impact factor: 6.277

Review 7.  Defining 'chromosomal instability'.

Authors:  Jochen B Geigl; Anna C Obenauf; Thomas Schwarzbraun; Michael R Speicher
Journal:  Trends Genet       Date:  2008-01-14       Impact factor: 11.639

8.  Somatic coding mutations in human induced pluripotent stem cells.

Authors:  Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

9.  p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Authors:  Abhinav K Jain; Kendra Allton; Michelina Iacovino; Elisabeth Mahen; Robert J Milczarek; Thomas P Zwaka; Michael Kyba; Michelle Craig Barton
Journal:  PLoS Biol       Date:  2012-02-28       Impact factor: 8.029

10.  Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Authors:  Alessandro Prigione; Amir M Hossini; Björn Lichtner; Akdes Serin; Beatrix Fauler; Matthias Megges; Rudi Lurz; Hans Lehrach; Eugenia Makrantonaki; Christos C Zouboulis; James Adjaye
Journal:  PLoS One       Date:  2011-11-14       Impact factor: 3.240
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  13 in total

Review 1.  Molecular mechanism of extrinsic factors affecting anti-aging of stem cells.

Authors:  Tzyy Yue Wong; Mairim Alexandra Solis; Ying-Hui Chen; Lynn Ling-Huei Huang
Journal:  World J Stem Cells       Date:  2015-03-26       Impact factor: 5.326

2.  21st Century Cell Culture for 21st Century Toxicology.

Authors:  David Pamies; Thomas Hartung
Journal:  Chem Res Toxicol       Date:  2016-12-05       Impact factor: 3.739

Review 3.  Stem cell therapy: old challenges and new solutions.

Authors:  Carmela Rita Balistreri; Elena De Falco; Antonella Bordin; Olga Maslova; Alexander Koliada; Alexander Vaiserman
Journal:  Mol Biol Rep       Date:  2020-03-03       Impact factor: 2.316

4.  Interaction between nonviral reprogrammed fibroblast stem cells and trophic factors for brain repair.

Authors:  G Liu; H Anisman; J Bobyn; S Hayley
Journal:  Mol Neurobiol       Date:  2014-03-28       Impact factor: 5.590

5.  Human ESC-derived Neuromesodermal Progenitors (NMPs) Successfully Differentiate into Mesenchymal Stem Cells (MSCs).

Authors:  Selinay Şenkal; Ayşegül Doğan; Taha Bartu Hayal; Derya Sağraç; Hatice Burcu Şişli; Ayla Burçin Asutay; Binnur Kıratlı; Engin Sümer; Albert A Rizvanov; Fikrettin Şahin
Journal:  Stem Cell Rev Rep       Date:  2021-10-20       Impact factor: 5.739

6.  Standardization of Cell Culture Conditions and Routine Genomic Screening under a Quality Management System Leads to Reduced Genomic Instability in hPSCs.

Authors:  Francisco J Molina-Ruiz; Clelia Introna; Georgina Bombau; Mireia Galofre; Josep M Canals
Journal:  Cells       Date:  2022-06-21       Impact factor: 7.666

7.  Look back in anger - what clinical studies tell us about preclinical work.

Authors:  Thomas Hartung
Journal:  ALTEX       Date:  2013       Impact factor: 6.043

8.  Nuclear reprogramming with a non-integrating human RNA virus.

Authors:  Christopher B Driscoll; Jason M Tonne; Moustafa El Khatib; Roberto Cattaneo; Yasuhiro Ikeda; Patricia Devaux
Journal:  Stem Cell Res Ther       Date:  2015-03-26       Impact factor: 6.832

9.  Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.

Authors:  Suomi M G Fouraschen; Joshua H Wolf; Luc J W van der Laan; Petra E de Ruiter; Wayne W Hancock; Job P van Kooten; Monique M A Verstegen; Kim M Olthoff; Jeroen de Jonge
Journal:  J Immunol Res       Date:  2015-08-24       Impact factor: 4.818

Review 10.  Stem cells in plastic surgery: a review of current clinical and translational applications.

Authors:  Ara A Salibian; Alan D Widgerow; Michael Abrouk; Gregory Rd Evans
Journal:  Arch Plast Surg       Date:  2013-11-08
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