Literature DB >> 23669310

Signaling networks of Rho GTPases in cell motility.

Samer Hanna1, Mirvat El-Sibai.   

Abstract

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.
Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Actin; Cancer; Motility; PI3K; Rho GTPases

Mesh：

Substances：

Year:  2013        PMID： 23669310     DOI： 10.1016/j.cellsig.2013.04.009

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


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