| Literature DB >> 23665071 |
Daniel Von Renteln1, Karl-Hermann Fuchs, Paul Fockens, Peter Bauerfeind, Melina C Vassiliou, Yuki B Werner, Gerald Fried, Wolfram Breithaupt, Henriette Heinrich, Albert J Bredenoord, Jan F Kersten, Tessa Verlaan, Michael Trevisonno, Thomas Rösch.
Abstract
Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.Entities:
Keywords: BTI; EBD; Endoscopic Therapy; Esophageal Motility Disorder; LES; LHM; POEM; PPI; Peroral Endoscopic Myotomy; botulinum toxin injection; endoscopic balloon dilatation; laparoscopic Heller myotomy; lower esophageal sphincter; peroral endoscopic myotomy; proton pump inhibitor
Mesh：
Year: 2013 PMID： 23665071 DOI： 10.1053/j.gastro.2013.04.057
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682