Literature DB >> 23663976

The structural basis for the allosteric regulation of ribonucleotide reductase.

Md Faiz Ahmad1, Chris G Dealwis.   

Abstract

Ribonucleotide reductases (RRs) catalyze a crucial step of de novo DNA synthesis by converting ribonucleoside diphosphates to deoxyribonucleoside diphosphates. Tight control of the dNTP pool is essential for cellular homeostasis. The activity of the enzyme is tightly regulated at the S-phase by allosteric regulation. Recent structural studies by our group and others provided the molecular basis for understanding how RR recognizes substrates, how it interacts with chemotherapeutic agents, and how it is regulated by its allosteric regulators ATP and dATP. This review discusses the molecular basis of allosteric regulation and substrate recognition of RR, and particularly the discovery that subunit oligomerization is an important prerequisite step in enzyme inhibition.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23663976      PMCID： PMC4059395          DOI： 10.1016/B978-0-12-386931-9.00014-3

Source DB:  PubMed          Journal:  Prog Mol Biol Transl Sci        ISSN： 1877-1173            Impact factor:   3.622


  73 in total

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Journal:  Org Lett       Date:  1999-10-21       Impact factor: 6.005

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Journal:  J Biol Chem       Date:  2000-10-20       Impact factor: 5.157

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Authors:  Reza Rofougaran; Munender Vodnala; Anders Hofer
Journal:  J Biol Chem       Date:  2006-07-22       Impact factor: 5.157

Review 4.  Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agents.

Authors:  Nuno M F S A Cerqueira; Pedro A Fernandes; Maria J Ramos
Journal:  Recent Pat Anticancer Drug Discov       Date:  2007-01       Impact factor: 4.169

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Journal:  FEBS Lett       Date:  1990-10-15       Impact factor: 4.124

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Authors:  R L Blakley; R K Ghambeer; P F Nixon; E Vitols
Journal:  Biochem Biophys Res Commun       Date:  1965-08-16       Impact factor: 3.575

7.  Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.

Authors:  Dinesh Kumar; Jörgen Viberg; Anna Karin Nilsson; Andrei Chabes
Journal:  Nucleic Acids Res       Date:  2010-03-09       Impact factor: 16.971

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Authors:  U Uhlin; H Eklund
Journal:  Nature       Date:  1994-08-18       Impact factor: 49.962

9.  Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors.

Authors:  Dianqing Sun; Hai Xu; Sanath R Wijerathna; Chris Dealwis; Richard E Lee
Journal:  ChemMedChem       Date:  2009-10       Impact factor: 3.466

Review 10.  Ribonucleotide reductases.

Authors:  A Jordan; P Reichard
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643
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  15 in total

1.  Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase.

Authors:  Andrew J Knappenberger; Sneha Grandhi; Reena Sheth; Md Faiz Ahmad; Rajesh Viswanathan; Michael E Harris
Journal:  J Biol Chem       Date:  2017-08-14       Impact factor: 5.157

2.  Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase.

Authors:  Sarah E Huff; Faiz Ahmad Mohammed; Mu Yang; Prashansa Agrawal; John Pink; Michael E Harris; Chris G Dealwis; Rajesh Viswanathan
Journal:  J Med Chem       Date:  2018-01-05       Impact factor: 7.446

3.  A continuous spectrophotometric enzyme-coupled assay for deoxynucleoside triphosphate triphosphohydrolases.

Authors:  Deepa Singh; Roel M Schaaper; Alejandro Hochkoeppler
Journal:  Anal Biochem       Date:  2015-12-23       Impact factor: 3.365

4.  Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli.

Authors:  Indu Kapoor; Elhassan Ali Fathi Emam; Abhirup Shaw; Umesh Varshney
Journal:  J Bacteriol       Date:  2019-12-06       Impact factor: 3.490

5.  Direct Measurement of the Radical Translocation Distance in the Class I Ribonucleotide Reductase from Chlamydia trachomatis.

Authors:  Jovan Livada; Ryan J Martinie; Laura M K Dassama; Carsten Krebs; J Martin Bollinger; Alexey Silakov
Journal:  J Phys Chem B       Date:  2015-06-30       Impact factor: 2.991

6.  Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis.

Authors:  Marcus J C Long; Yi Zhao; Yimon Aye
Journal:  Cell Chem Biol       Date:  2019-12-10       Impact factor: 8.116

7.  The expression of ribonucleotide reductase M2 in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients.

Authors:  Ying-Fang Su; Tzu-Fan Wu; Jiunn-Liang Ko; Hsiu-Ting Tsai; Yi-Torng Tee; Ming-Hsien Chien; Chi-Hung Chou; Wea-Lung Lin; Hui-Ying Low; Ming-Yung Chou; Shun-Fa Yang; Po-Hui Wang
Journal:  PLoS One       Date:  2014-03-17       Impact factor: 3.240

Review 8.  Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction.

Authors:  Sam L Teichman; Kassandra S Thomson; Michael Regnier
Journal:  Handb Exp Pharmacol       Date:  2017

Review 9.  Ribonucleotide reductases: essential enzymes for bacterial life.

Authors:  Eduard Torrents
Journal:  Front Cell Infect Microbiol       Date:  2014-04-28       Impact factor: 5.293

10.  Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.

Authors:  Mahmudul Hasan; Mikael Crona; Venkateswara Rao Jonna; Inna Rozman Grinberg; Daniel Lundin; Christoph Loderer; Margareta Sahlin; Natalia Markova; Ilya Borovok; Gustav Berggren; Anders Hofer; Derek T Logan; Britt-Marie Sjöberg
Journal:  Elife       Date:  2018-02-01       Impact factor: 8.140
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