| Literature DB >> 10825970 |
S Liehr1, J Barbosa, A B Smith, B S Cooperman.
Abstract
[formula: see text] A series of lactam-bridged peptide inhibitors (2-6) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized on the basis of the heptapeptide N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed a direct relation between ring size and activity, with peptide 5 being 2.5 times more potent than peptide 1.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10825970 DOI： 10.1021/ol9909381
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005