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Literature DB >> 23661364

Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction.

Seongjoon Park¹, Ryoichi Mori, Isao Shimokawa.

Abstract

Sirtuins (SIRTs), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, are emerging as key molecules that regulate aging and age-related diseases including cancers, metabolic disorders, and neurodegenerative diseases. Seven isoforms of SIRT (SIRT1-7) have been identified in mammals. SIRT1 and 6, mainly localized in the nucleus, regulate transcription of genes and DNA repair. SIRT3 in the mitochondria regulates mitochondrial bioenergetics. Initial studies in yeasts, nematodes, and flies indicated a strong connection of SIRT with the life-prolonging effects of calorie restriction (CR), a robust experimental intervention for longevity in a range of organisms. However, subsequent studies reported controversial findings regarding SIRT roles in the effect of CR. This review describes the functional roles of mammalian SIRTs and discusses their relevance to mechanisms underlying the longevity effect of CR.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Sirtuins

Year: 2013 PMID： 23661364 PMCID： PMC3887872 DOI： 10.1007/s10059-013-0130-x

Source DB: PubMed Journal: Mol Cells ISSN： 1016-8478 Impact factor: 5.034

100 in total

Review 1. How does calorie restriction work?

Authors: Jana Koubova; Leonard Guarente
Journal: Genes Dev Date: 2003-02-01 Impact factor: 11.361

2. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.

Authors: Sylvia C Dryden; Fatimah A Nahhas; James E Nowak; Anton-Scott Goustin; Michael A Tainsky
Journal: Mol Cell Biol Date: 2003-05 Impact factor: 4.272

3. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

Authors: Brian J North; Brett L Marshall; Margie T Borra; John M Denu; Eric Verdin
Journal: Mol Cell Date: 2003-02 Impact factor: 17.970

4. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Authors: Kevin J Bitterman; Rozalyn M Anderson; Haim Y Cohen; Magda Latorre-Esteves; David A Sinclair
Journal: J Biol Chem Date: 2002-09-23 Impact factor: 5.157

5. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.

Authors: Patrick Onyango; Ivana Celic; J Michael McCaffery; Jef D Boeke; Andrew P Feinberg
Journal: Proc Natl Acad Sci U S A Date: 2002-10-08 Impact factor: 11.205

6. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

7. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors: Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Journal: Science Date: 2004-02-19 Impact factor: 47.728

Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction.

Review 1. How does calorie restriction work?

2. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.

3. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

4. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

5. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.

6. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

7. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

8. Calorie restriction extends yeast life span by lowering the level of NADH.

9. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.

10. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

1. Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata).

Review 2. Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.

Review 3. Senescence suppressors: their practical importance in replicative lifespan extension in stem cells.

4. Advanced glycation end products, dementia, and diabetes.

5. SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.

6. SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.

Review 7. Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells.

Review 8. Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies.

Review 9. Mitochondrial dysfunction in cardiac aging.

Review 10. Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes.