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Literature DB >> 25890999

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.

Xi Chen^1,2, Yun Lu^1,2, Zhengguo Zhang^1,2, Jian Wang^1,2, Hui Yang^1,2, Guangwei Liu^1,2.

Abstract

Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in understanding the regulatory role of Sirt1 in immune responses as well as how Sirt1 translates metabolic cues to immune signals, which would bring new insights into both pathogenesis and potential therapeutic strategies of a variety of immune-related diseases, such as cancer, microbial infection, autoimmune diseases and transplantation.

Entities: Disease Gene Species

Keywords: Sirt1; T-cell activation; immune diseases; innate immune cells; metabolism; myeloid-derived suppressor cells; regulatory T cells

Mesh：

Substances：

Year: 2015 PMID： 25890999 PMCID： PMC4515126 DOI： 10.1111/imm.12473

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

158 in total

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Journal: J Biol Chem Date: 2012-08-14 Impact factor: 5.157

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7. STAT3 inhibition of gluconeogenesis is downregulated by SirT1.

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Journal: Nat Cell Biol Date: 2009-03-22 Impact factor: 28.824

8. NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

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Journal: Blood Date: 2018-12-04 Impact factor: 22.113

Review 2. Neurotherapeutic capacity of P7C3 agents for the treatment of Traumatic Brain Injury.

Authors: Meghan O Blaya; Joseph M Wasserman; Andrew A Pieper; Thomas J Sick; Helen M Bramlett; W Dalton Dietrich
Journal: Neuropharmacology Date: 2018-09-17 Impact factor: 5.250

3. Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-γ in psoriatic patients.

Authors: H Rasheed; Mhm El-Komy; R A Hegazy; H I Gawdat; A M AlOrbani; O G Shaker
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4. How T'reg-ulate healing of the injured spinal cord?

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6. Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.

Authors: Tomomi Toubai; Hiroya Tamaki; Daniel C Peltier; Corinne Rossi; Katherine Oravecz-Wilson; Chen Liu; Cynthia Zajac; Julia Wu; Yaping Sun; Hideaki Fujiwara; Israel Henig; Stephanie Kim; David B Lombard; Pavan Reddy
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Review 7. The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus.

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Journal: Front Immunol Date: 2021-04-26 Impact factor: 7.561

Review 8. Adjunct Strategies for Tuberculosis Vaccines: Modulating Key Immune Cell Regulatory Mechanisms to Potentiate Vaccination.

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9. NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70.

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Review 10. Lipid droplets and the host-pathogen dynamic: FATal attraction?

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