Literature DB >> 23659282

Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).

Wei-Lun Yu1, Brian D Jones, Minjin Kang, Justin C Hammons, James J La Clair, Michael D Burkart.   

Abstract

Spirohexenolides A and B comprise a unique family of spirotetronate natural products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity-fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.

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Year:  2013        PMID： 23659282      PMCID： PMC3706094          DOI： 10.1021/np3004497

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  28 in total

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Review 6.  Chemical proteomics approaches for identifying the cellular targets of natural products.

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