Literature DB >> 23652020

Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.

Simon Kang Seng Ting1, Mei-Sian Chong, Nagaendran Kandiah, Shahul Hameed, Louis Tan, Wing-Lok Au, Kumar M Prakash, Ratnagopal Pavanni, Tih-Shih Lee, Jia-Nee Foo, Jin-Xin Bei, Xue-Qing Yu, Jian-Jun Liu, Yi Zhao, Wei-Ling Lee, Eng-King Tan.   

Abstract

The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.
Copyright © 2013. Published by Elsevier Inc.

Entities:  

Keywords:  A673T; Amyloid-beta precursor protein; Dementia

Mesh：

Substances：

Year:  2013        PMID： 23652020     DOI： 10.1016/j.neurobiolaging.2013.04.012

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  12 in total

Review 1.  Protective alleles and modifier variants in human health and disease.

Authors:  Andrew R Harper; Shalini Nayee; Eric J Topol
Journal:  Nat Rev Genet       Date:  2015-10-27       Impact factor: 53.242

2.  Novel susceptibility loci for Alzheimer's disease.

Authors:  Christiane Reitz
Journal:  Future Neurol       Date:  2015-12

Review 3.  Exploring the Involvement of the Amyloid Precursor Protein A673T Mutation against Amyloid Pathology and Alzheimer's Disease in Relation to Therapeutic Editing Tools.

Authors:  Gabriela Dumitrita Stanciu; Daniela Carmen Ababei; Razvan Nicolae Rusu; Veronica Bild; Bogdan-Ionel Tamba
Journal:  Pharmaceutics       Date:  2022-06-15       Impact factor: 6.525

4.  Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

Authors:  Mikhil N Bamne; F Yesim Demirci; Sarah Berman; Beth E Snitz; Samantha L Rosenthal; Xingbin Wang; Oscar L Lopez; M Ilyas Kamboh
Journal:  Neurobiol Aging       Date:  2014-01-23       Impact factor: 4.673

5.  The APP A673T frequency differs between Nordic countries.

Authors:  Jonas Mengel-From; Bernard Jeune; Tienari Pentti; Matt McGue; Kaare Christensen; Lene Christiansen
Journal:  Neurobiol Aging       Date:  2015-07-11       Impact factor: 4.673

6.  Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:  Li-San Wang; Adam C Naj; Robert R Graham; Paul K Crane; Brian W Kunkle; Carlos Cruchaga; Josue D Gonzalez Murcia; Lisa Cannon-Albright; Clinton T Baldwin; Henrik Zetterberg; Kaj Blennow; Walter A Kukull; Kelley M Faber; Nicole Schupf; Maria C Norton; JoAnn T Tschanz; Ronald G Munger; Christopher D Corcoran; Ekaterina Rogaeva; Chiao-Feng Lin; Beth A Dombroski; Laura B Cantwell; Amanda Partch; Otto Valladares; Hakon Hakonarson; Peter St George-Hyslop; Robert C Green; Alison M Goate; Tatiana M Foroud; Regina M Carney; Eric B Larson; Timothy W Behrens; John S K Kauwe; Jonathan L Haines; Lindsay A Farrer; Margaret A Pericak-Vance; Richard Mayeux; Gerard D Schellenberg; Marilyn S Albert; Roger L Albin; Liana G Apostolova; Steven E Arnold; Robert Barber; Michael Barmada; Lisa L Barnes; Thomas G Beach; James T Becker; Gary W Beecham; Duane Beekly; David A Bennett; Eileen H Bigio; Thomas D Bird; Deborah Blacker; Bradley F Boeve; James D Bowen; Adam Boxer; James R Burke; Joseph D Buxbaum; Nigel J Cairns; Chuanhai Cao; Chris S Carlson; Steven L Carroll; Helena C Chui; David G Clark; David H Cribbs; Elizabeth A Crocco; Charles DeCarli; Steven T DeKosky; F Yesim Demirci; Malcolm Dick; Dennis W Dickson; Ranjan Duara; Nilufer Ertekin-Taner; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Jonathan D Glass; Neill R Graff-Radford; John H Growdon; Ronald L Hamilton; Kara L Hamilton-Nelson; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gail P Jarvik; Gregory A Jicha; Lee-Way Jin; Gyungah Jun; Gyungah Jun; M Ilyas Kamboh; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; Joel H Kramer; Frank M LaFerla; James J Lah; James B Leverenz; Allan I Levey; Gei Li; Andrew P Lieberman; Oscar L Lopez; Kathryn L Lunetta; Constantine G Lyketsos; Wendy J Mack; Daniel C Marson; Eden R Martin; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; W Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Thomas J Montine; John C Morris; Jill R Murrell; John M Olichney; Joseph E Parisi; William Perry; Elaine Peskind; Ronald C Petersen; Aimee Pierce; Wayne W Poon; Huntington Potter; Joseph F Quinn; Ashok Raj; Murray Raskind; Eric M Reiman; Barry Reisberg; Christiane Reitz; John M Ringman; Erik D Roberson; Howard J Rosen; Roger N Rosenberg; Mary Sano; Andrew J Saykin; Julie A Schneider; Lon S Schneider; William W Seeley; Amanda G Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; Tricia A Thornton-Wells; John Q Trojanowski; Juan C Troncoso; Debby W Tsuang; Vivianna M Van Deerlin; Linda J Van Eldik; Badri N Vardarajan; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Sarah Wishnek; Randall L Woltjer; Clinton B Wright; Steven G Younkin; Chang-En Yu; Lei Yu
Journal:  JAMA Neurol       Date:  2015-02       Impact factor: 18.302

Review 7.  Identification of rare variants in Alzheimer's disease.

Authors:  Jenny Lord; Alexander J Lu; Carlos Cruchaga
Journal:  Front Genet       Date:  2014-10-28       Impact factor: 4.599

Review 8.  Genes associated with Alzheimer's disease: an overview and current status.

Authors:  Mohan Giri; Man Zhang; Yang Lü
Journal:  Clin Interv Aging       Date:  2016-05-17       Impact factor: 4.458

9.  The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Authors:  Asuka Kokawa; Seiko Ishihara; Hitomi Fujiwara; Mika Nobuhara; Minori Iwata; Yasuo Ihara; Satoru Funamoto
Journal:  Acta Neuropathol Commun       Date:  2015-11-04       Impact factor: 7.801

10.  Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.

Authors:  Kenichi Nagata; Mika Takahashi; Yukio Matsuba; Fumi Okuyama-Uchimura; Kaori Sato; Shoko Hashimoto; Takashi Saito; Takaomi C Saido
Journal:  Nat Commun       Date:  2018-05-04       Impact factor: 14.919
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