Literature DB >> 2364983

Biological activity of N-terminal fragments of calcitonin gene-related peptide.

C A Maggi1, P Rovero, S Giuliani, S Evangelista, D Regoli, A Meli.   

Abstract

The i.v. injection of human alpha-calcitonin gene-related peptide (CGRP) in urethane-anesthetized rats produced hypotension and tachycardia. The N-terminal fragments, CGRP-(1-12), CGRP-(1-15) and CGRP-(1-22) displayed biological activity, although with less potency than the natural peptide. These findings provide the first evidence for biological agonist activity of N-terminal CGRP fragments.

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Year:  1990        PMID： 2364983     DOI： 10.1016/0014-2999(90)90422-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.

Authors:  J A Hubbard; S R Martin; L C Chaplin; C Bose; S M Kelly; N C Price
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

Review 2.  Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine.

Authors:  Paul L Durham
Journal:  Headache       Date:  2008-09       Impact factor: 5.887

3.  Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Authors:  Paul L Durham; Carrie V Vause
Journal:  CNS Drugs       Date:  2010-07       Impact factor: 5.749

4.  Identification of the epitopes of calcitonin gene-related peptide (CGRP) for two anti-CGRP monoclonal antibodies by 2D NMR.

Authors:  J A Hubbard; D P Raleigh; J R Bonnerjea; C M Dobson
Journal:  Protein Sci       Date:  1997-09       Impact factor: 6.725

5.  On the role of the C-terminus of alpha-calcitonin-gene-related peptide (alpha CGRP). The structure of des-phenylalaninamide37-alpha CGRP and its interaction with the CGRP receptor.

Authors:  J P O'Connell; S M Kelly; D P Raleigh; J A Hubbard; N C Price; C M Dobson; B J Smith
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

6.  The effect of monoclonal antibodies to calcitonin gene-related peptide (CGRP) on CGRP-induced vasodilatation in pig coronary artery rings.

Authors:  N E Shaw; R Foulkes; D P Andrew; D T Brown; B Hughes
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739

7.  Interaction of human adrenomedullin 13-52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster.

Authors:  J M Hall; L Siney; H Lippton; A Hyman; J Kang-Chang; S D Brain
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

8.  Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes.

Authors:  D R Poyner; D P Andrew; D Brown; C Bose; M R Hanley
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

Review 9.  Structure-activity relationships for α-calcitonin gene-related peptide.

Authors:  Harriet A Watkins; Dan L Rathbone; James Barwell; Debbie L Hay; David R Poyner
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

10.  Role of calcitonin gene-related peptide in cerebral vasospasm, and as a therapeutic approach to subarachnoid hemorrhage.

Authors:  Stelios Kokkoris; Peter Andrews; David J Webb
Journal:  Front Endocrinol (Lausanne)       Date:  2012-11-15       Impact factor: 5.555
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