Literature DB >> 23649668

The corneal transplant score: a simple corneal graft candidate calculator.

Eldar Rosenfeld1, David Varssano.   

Abstract

BACKGROUND: Shortage of corneas for transplantation has created long waiting lists in most countries. Transplant calculators are available for many organs. The purpose of this study is to describe a simple automatic scoring system for keratoplasty recipient candidates, based on several parameters that we consider most relevant for tissue allocation, and to compare the system's accuracy in predicting decisions made by a cornea specialist.
METHODS: Twenty pairs of candidate data were randomly created on an electronic spreadsheet. A single priority score was computed from the data of each candidate. A cornea surgeon and the automated system then decided independently which candidate in each pair should have surgery if only a single cornea was available.
RESULTS: The scoring system can calculate values between 0 (lowest priority) and 18 (highest priority) for each candidate. Average score value in our randomly created cohort was 6.35 ± 2.38 (mean ± SD), range 1.28 to 10.76. Average score difference between the candidates in each pair was 3.12 ± 2.10, range 0.08 to 8.45. The manual scoring process, although theoretical, was mentally and emotionally demanding for the surgeon. Agreement was achieved between the human decision and the calculated value in 19 of 20 pairs. Disagreement was reached in the pair with the lowest score difference (0.08).
CONCLUSIONS: With worldwide donor cornea shortage, waiting for transplantation can be long. Manual sorting of priority for transplantation in a long waiting list is difficult, time-consuming and prone to error. The suggested system may help achieve a justified distribution of available tissue.

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Year:  2013        PMID: 23649668     DOI: 10.1007/s00417-013-2358-8

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN: 0721-832X            Impact factor:   3.117


  18 in total

1.  Successful homotransplantation of the human kidney between identical twins.

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3.  Outcome of corneal transplantation: can a prioritisation system predict outcome?

Authors:  Patrick P R Saunders; Lyn M Sibley; John S F Richards; Simon P Holland; Debbie L Chow; Paul Courtright
Journal:  Br J Ophthalmol       Date:  2002-01       Impact factor: 4.638

Review 4.  Prioritization for liver transplantation.

Authors:  Evangelos Cholongitas; Giacomo Germani; Andrew K Burroughs
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2010-11-02       Impact factor: 46.802

Review 5.  The calculated panel reactive antibody policy: an advancement improving organ allocation.

Authors:  Mary S Leffell
Journal:  Curr Opin Organ Transplant       Date:  2011-08       Impact factor: 2.640

6.  The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town.

Authors:  C N Barnard
Journal:  S Afr Med J       Date:  1967-12-30

7.  Extended survival in 3 cases of orthotopic homotransplantation of the human liver.

Authors:  T E Starzl; C G Groth; L Brettschneider; J B Moon; V A Fulginiti; E K Cotton; K A Porter
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8.  Creation of priority criteria for corneal transplantation and analysis of factors associated with surgery following implementation.

Authors:  P Courtright; C I Poon; J S Richards; D L Chow; G Ottenbreit; S P Holland
Journal:  Can J Public Health       Date:  1997 Sep-Oct

Review 9.  Organ allocation in lung transplant.

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Journal:  Chest       Date:  2007-11       Impact factor: 9.410

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Authors:  Benjamin D Kozower; Bryan F Meyers; Michael A Smith; Nilto C De Oliveira; Stephen D Cassivi; Tracey J Guthrie; Honkung Wang; Beverly J Ryan; K Robert Shen; Thomas M Daniel; David R Jones
Journal:  J Thorac Cardiovasc Surg       Date:  2007-11-12       Impact factor: 5.209

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2.  Considerations for Corneal Surgery With Patients in the 10th Decade of Life.

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3.  Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation.

Authors:  M Mirazul Islam; Oleksiy Buznyk; Jagadesh C Reddy; Nataliya Pasyechnikova; Keith M Meek; Virender S Sangwan; May Griffith; Emilio I Alarcon; Sally Hayes; Philip Lewis; Per Fagerholm; Chaoliang He; Stanislav Iakymenko; Wenguang Liu
Journal:  NPJ Regen Med       Date:  2018-01-31
  3 in total

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