Chia-Yi Lee1, Hung-Ta Chen2, Yi-Jen Hsueh3, Hung-Chi Chen3, Chieh-Cheng Huang4, Yaa-Jyuhn James Meir5, Chao-Min Cheng4, Wei-Chi Wu3. 1. Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 50093, Taiwan. 2. Department of Internal Medicine, Taipei City Hospital- Heping Branch, Taipei 10341, Taiwan. 3. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 20012, Taiwan. 4. Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 20012, Taiwan. 5. Department of Biomedical Sciences, College of Medicine Chang Gung University, Taoyuan 33305, Taiwan.
Abstract
BACKGROUND: The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid (AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation. CASE SUMMARY: Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy (Patient 1) and endotheliitis (Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity (BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years. CONCLUSION: Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.
BACKGROUND: The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid (AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation. CASE SUMMARY: Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy (Patient 1) and endotheliitis (Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity (BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years. CONCLUSION: Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.
Entities:
Keywords:
Ascorbic acid; Case report; Endotheliitis; Fuchs corneal endothelial dystrophy; Human corneal endothelial cell; Phacoemulsification
Authors: S C Brodovsky; C A McCarty; G Snibson; M Loughnan; L Sullivan; M Daniell; H R Taylor Journal: Ophthalmology Date: 2000-10 Impact factor: 12.079